MAFLD with central obesity is associated with increased risk of colorectal adenoma and high-risk adenoma

Jingfang Xiong; Yijun Wu; Dongya Chen; Zhaolin Zhang; Yihui Liu; Jiandong Luo; Hong Xu

doi:10.1186/s12876-024-03220-z

MAFLD with central obesity is associated with increased risk of colorectal adenoma and high-risk adenoma

BMC Gastroenterol. 2024 Apr 22;24(1):138. doi: 10.1186/s12876-024-03220-z.

Authors

Jingfang Xiong¹, Yijun Wu², Dongya Chen³, Zhaolin Zhang³, Yihui Liu³, Jiandong Luo⁴, Hong Xu^{5

6}

Affiliations

¹ Department of Geriatrics, Hangzhou Red Cross Hospital, Hangzhou City, Zhejiang Province, China.
² The 2nd Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou City, Zhejiang Province, China.
³ Department of Gastroenterology and Hepatology, Hangzhou Red Cross Hospital, Hangzhou City, Zhejiang Province, China.
⁴ Endoscopy Center, Hangzhou Red Cross Hospital, Hangzhou City, Zhejiang Province, China.
⁵ Department of Gastroenterology and Hepatology, Hangzhou Red Cross Hospital, Hangzhou City, Zhejiang Province, China. hongxuhzrc@aliyun.com.
⁶ Department of Gastroenterology and Hepatology, Hangzhou Red Cross Hospital, 208 Huancheng Dong Road, 310003, Hangzhou, China. hongxuhzrc@aliyun.com.

Abstract

Objective: To analyze the risk factors associated with colorectal adenoma and to investigate the associations of metabolism-related fatty liver disease (MAFLD) with obesity, colorectal adenoma and high-risk adenoma.

Methods: A total of 1395 subjects were enrolled and divided into a colorectal adenoma group (593 subjects) and a control group (802 subjects) according to the inclusion and exclusion criteria. The characteristics of patients in the colorectal adenoma group and the control group were compared by the chi-square test. Univariate and multivariate logistic analyses were used to analyze independent risk factors and associations with different MAFLD subtypes. Colorectal adenoma characteristics and the proportion of patients with high-risk colorectal adenoma were also compared.

Results: High-density lipoprotein (HDL-C) was significantly lower in patients in the colorectal adenoma group than in those in the control group (P < 0.001). Logistic regression analysis revealed that age, obesity status, central obesity status, hypertension status, diabetes status, fatty liver status, smoking history, BMI, waist circumference, triglyceride level, HDL-C level, fasting blood glucose level and degree of hepatic steatosis were all independent risk factors for colorectal adenoma. Notably, MAFLD was associated with a significantly increased risk of colorectal adenoma in patients with central obesity (P < 0.001). In addition, obesity, central obesity, diabetes, fatty liver and degree of hepatic steatosis were all shown to be independent risk factors for high-risk colorectal adenoma. In addition, a greater proportion of MAFLD patients with central obesity than those without central obesity had high-risk colorectal adenoma.

Conclusion: MAFLD and central obesity are independently associated with the development of colorectal adenoma. MAFLD with central obesity is associated with an increased risk of colorectal adenoma and high-risk adenoma.

Keywords: Central obesity; Colorectal adenoma; High-risk adenoma; MAFLD.

MeSH terms

Adenoma* / epidemiology
Adult
Aged
Case-Control Studies
Colorectal Neoplasms* / epidemiology
Colorectal Neoplasms* / etiology
Fatty Liver / complications
Fatty Liver / epidemiology
Female
Humans
Logistic Models
Male
Middle Aged
Obesity, Abdominal* / complications
Obesity, Abdominal* / epidemiology
Risk Factors
Waist Circumference