Inhibition of UHRF1 Improves Motor Function in Mice with Spinal Cord Injury

Cell Mol Neurobiol. 2024 Apr 22;44(1):39. doi: 10.1007/s10571-024-01474-5.

Abstract

Spinal-cord injury (SCI) is a severe condition that can lead to limb paralysis and motor dysfunction, and its pathogenesis is not fully understood. The objective of this study was to characterize the differential gene expression and molecular mechanisms in the spinal cord of mice three days after spinal cord injury. By analyzing RNA sequencing data, we identified differentially expressed genes and discovered that the immune system and various metabolic processes play crucial roles in SCI. Additionally, we identified UHRF1 as a key gene that plays a significant role in SCI and found that SCI can be improved by suppressing UHRF1. These findings provide important insights into the molecular mechanisms of SCI and identify potential therapeutic targets that could greatly contribute to the development of new treatment strategies for SCI.

Keywords: Immunity; Microenvironment; Molecular regulation; Spinal-cord injury; UHRF1.

MeSH terms

  • Animals
  • CCAAT-Enhancer-Binding Proteins* / genetics
  • CCAAT-Enhancer-Binding Proteins* / metabolism
  • Female
  • Gene Expression Regulation
  • Mice
  • Mice, Inbred C57BL
  • Motor Activity / physiology
  • Recovery of Function / physiology
  • Spinal Cord / metabolism
  • Spinal Cord / pathology
  • Spinal Cord Injuries* / physiopathology
  • Ubiquitin-Protein Ligases* / genetics
  • Ubiquitin-Protein Ligases* / metabolism

Substances

  • Ubiquitin-Protein Ligases
  • CCAAT-Enhancer-Binding Proteins
  • Uhrf1 protein, mouse