Controlled Calcium Oxalate Crystals Obtained by Electrocrystallization on Electrospun Polycaprolactone Fibers Loaded with Zarzaparrilla ( Herreria stellata )

Andrónico Neira-Carrillo; Tatiana Zegers Arce; Mehrdad Yazdani-Pedram

doi:10.1021/acsomega.3c08736

Controlled Calcium Oxalate Crystals Obtained by Electrocrystallization on Electrospun Polycaprolactone Fibers Loaded with Zarzaparrilla ( Herreria stellata )

ACS Omega. 2024 Apr 6;9(15):17045-17053. doi: 10.1021/acsomega.3c08736. eCollection 2024 Apr 16.

Authors

Andrónico Neira-Carrillo¹, Tatiana Zegers Arce¹, Mehrdad Yazdani-Pedram²

Affiliations

¹ Department of Biological and Animal Science, Faculty of Veterinary and Animal Sciences, Universidad de Chile, Santa Rosa 11735, La Pintana, Santiago 1025000, Chile.
² Department of Organic and Physical Chemistry, Faculty of Chemical and Pharmaceutical Sciences, Universidad de Chile, Olivos 1007, Independencia, Santiago 8380492, Chile.

Abstract

Calcium oxalate (CaOx) is known to grow on organic matrices and is often associated with the formation of kidney stones. Therefore, it is crucial to understand the nucleation and growth mechanisms. This study investigates the role of electrospun polycaprolactone (PCL)-loaded zarzaparrilla (ZP) (Herreria stellata) in the electrocrystallization (EC) of CaOx. Electrospinning (ES) was used to prepare PCL meshes with random (R) and aligned (A) fiber orientations. CaOx particles were grown directly on conductive tin indium oxide (ITO) glass modified with electrospun ZP-loaded PCL meshes by EC. The CaOx crystals after EC were measured by chronopotentiometry (CP), optical microscopy (OM), scanning electron microscopy (SEM), and X-ray diffraction (XRD), which showed that the ZP additive and PCL fiber orientations are key factors for CaOx nucleation.