Tenascin-C (TNC) is a matricellular and multimodular glycoprotein highly expressed under pathological conditions, especially in cancer and chronic inflammatory diseases. Since a long time TNC is considered as a promising target for diagnostic and therapeutic approaches in anti-cancer treatments and was already extensively targeted in clinical trials on cancer patients. This review provides an overview of the current most advanced strategies used for TNC detection and anti-TNC theranostic approaches including some advanced clinical strategies. We also discuss novel treatment protocols, where targeting immune modulating functions of TNC could be center stage.
Keywords: Tenascin-C; antibody; aptamer; biomarker; cancer; diagnostic application; extracellular matrix; inflammation; nanobody; peptide; therapeutic approach; tumor; tumor immunity.
Copyright © 2024. Published by Elsevier B.V.