The obesity paradox exists for perioperative complications and mortality following lower extremity arterial bypass surgery

Mokhshan Ramachandran; Jonathan T Unkart; Daniel Willie-Permor; Mohammed Hamouda; Nadin Elsayed; Mahmoud B Malas

doi:10.1016/j.jvs.2024.04.044

The obesity paradox exists for perioperative complications and mortality following lower extremity arterial bypass surgery

J Vasc Surg. 2024 Apr 18:S0741-5214(24)01067-X. doi: 10.1016/j.jvs.2024.04.044. Online ahead of print.

Authors

Mokhshan Ramachandran¹, Jonathan T Unkart², Daniel Willie-Permor¹, Mohammed Hamouda¹, Nadin Elsayed¹, Mahmoud B Malas³

Affiliations

¹ Division of Vascular Surgery, Department of Surgery, Center for Learning and Excellence in Vascular and Endovascular Research (CLEVER), UC San Diego, San Diego, CA.
² Department of Surgery, SUNY Downstate Medical Center, Brooklyn, NY.
³ Division of Vascular Surgery, Department of Surgery, Center for Learning and Excellence in Vascular and Endovascular Research (CLEVER), UC San Diego, San Diego, CA. Electronic address: mmalas@health.ucsd.edu.

PMID: 38642672
DOI: 10.1016/j.jvs.2024.04.044

Abstract

Objective: The obesity paradox refers to a phenomenon by which obese individuals experience lower risk of mortality and even protective associations from chronic disease sequelae when compared with the non-obese and underweight population. Prior literature has demonstrated an obesity paradox after cardiac and other surgical procedures. However, the relationship between body mass index (BMI) and perioperative complications for patients undergoing major open lower extremity arterial revascularization is unclear.

Methods: We queried the Vascular Quality Initiative for individuals receiving unilateral infrainguinal bypass between 2003 and 2020. We used multivariable logistic regression to assess the relationship of BMI categories (underweight [<18.5 kg/m²], non-obese [18.5-24.9 kg/m²], overweight [25-29.9 kg/m²], Class 1 obesity [30-34.9 kg/m²], Class 2 obesity [35-39.9 kg/m²], and Class 3 obesity [>40 kg/m²]) with 30-day mortality, surgical site infection, and adverse cardiovascular events. We adjusted the models for key patient demographics, comorbidities, and technical and perioperative characteristics.

Results: From 2003 to 2020, 60,588 arterial bypass procedures met inclusion criteria for analysis. Upon multivariable logistic regression with the non-obese category as the reference group, odds of 30-day mortality were significantly decreased among the overweight (odds ratio [OR], 0.64; 95% confidence interval [CI], 0.53-0.78), Class 1 obese (OR, 0.65; 95% CI, 0.52-0.81), Class 2 obese (OR, 0.66; 95% CI, 0.48-0.90), and Class 3 obese (OR, 0.61; 95% CI, 0.39-0.97) patient categories. Conversely, odds of 30-day mortality were increased in the underweight patient group (OR, 1.58; 95% CI, 1.16-2.13). Furthermore, a BMI-dependent positive association was present, with odds of surgical site infections with patients in Class 3 obesity having the highest odds (OR, 2.10; 95% CI, 1.60-2.76). Finally, among the adverse cardiovascular event outcomes assessed, only myocardial infarction (MI) demonstrated decreased odds among overweight (OR, 0.82; 95% CI, 0.71-0.96), Class 1 obese (OR, 0.78; 95% CI, 0.65-0.93), and Class 2 obese (OR, 0.66; 95% CI, 0.51-0.86) patient populations. Odds of MI among the underweight and Class 3 obesity groups were not significant.

Conclusions: The obesity paradox is evident in patients undergoing lower extremity bypass procedures, particularly with odds of 30-day mortality and MI. Our findings suggest that having higher BMI (overweight and Class 1-3 obesity) is not associated with increased mortality and should not be interpreted as a contraindication for lower extremity arterial bypass surgery. However, these patients should be under vigilant surveillance for surgical site infections. Finally, patients that are underweight have a significantly increased odds of 30-day mortality and may be more suitable candidates for endovascular therapy.

Keywords: BMI; Death; Infection; Infrainguinal; Myocardial infarction.