Research update for ferroptosis and cholangiocarcinoma

Shengfeng Fu; Qinyang Zhang; Changhe Zhang

doi:10.1016/j.critrevonc.2024.104356

Research update for ferroptosis and cholangiocarcinoma

Crit Rev Oncol Hematol. 2024 Apr 18:198:104356. doi: 10.1016/j.critrevonc.2024.104356. Online ahead of print.

Authors

Shengfeng Fu¹, Qinyang Zhang², Changhe Zhang³

Affiliations

¹ Department of General Surgery, Taizhou people's Hospital, Nanjing Medical University, Taizhou, China; Postgraduate School, Dalian Medical University, Dalian, China.
² Department of Orthopedics, Taizhou people's Hospital, Nanjing Medical University, Taizhou, Taizhou, China; Postgraduate School, Dalian Medical University, Dalian, China. Electronic address: surgzqy@163.com.
³ Department of General Surgery, Taizhou people's Hospital, Nanjing Medical University, Taizhou, China. Electronic address: zhangchanghe@njmu.edu.cn.

PMID: 38641134
DOI: 10.1016/j.critrevonc.2024.104356

Abstract

Cholangiocarcinoma (CCA) is the second most common hepatobiliary malignancy after hepatocellular carcinoma. Due to the poor treatment effect and high mortality rate of CCA, it is of great significance to explore new therapeutic targets. Ferroptosis is a type of cell death caused by iron-dependent cell oxidative injury, which is closely related to the occurrence and development of numerous diseases. Novel ideas for the prevention and treatment of related diseases have been provided by ferroptosis, which has become a focus of research in recent years. This review introduces the underlying mechanisms related to ferroptosis, as well as a research update for ferroptosis in the occurrence and development of CCA. The clinical value of ferroptosis-related regulatory mechanisms in CCA will be elucidated.

Keywords: Cholangiocarcinoma; Ferroptosis; Iron metabolism; Oxidative stress; Review.

Publication types

Review