Entangling and disentangling mitotic chromosomes

Jonathan Baxter

doi:10.1016/j.molcel.2024.03.025

Entangling and disentangling mitotic chromosomes

Mol Cell. 2024 Apr 18;84(8):1398-1400. doi: 10.1016/j.molcel.2024.03.025.

Author

Jonathan Baxter¹

Affiliation

¹ Genome Damage and Stability Centre, School of Life Sciences, Science Park Road, University of Sussex, Falmer, Brighton, East Sussex BN1 9RQ, UK. Electronic address: jon.baxter@sussex.ac.uk.

PMID: 38640891
DOI: 10.1016/j.molcel.2024.03.025

Abstract

The DNA topological challenges generated by cellular manipulation of extremely long DNA fibers remain poorly understood. In this issue of Molecular Cell, Hildebrand et al.¹ describe how mitotic chromosomes are self entangled and that disentanglement requires TOP2 activity in late mitosis.

MeSH terms

Chromosomes* / genetics
DNA / genetics
DNA Topoisomerases, Type II* / genetics
Mitosis / genetics

Substances

DNA Topoisomerases, Type II
DNA