Adherence to oxidative balance score is inversely associated with the prevalence of stroke: results from National Health and Nutrition Examination Survey 1999-2018

Jiarui Chen; Jianjian Liu; Zhaowen Gu; Jiayong Fan; Shuxin Lei; Qia Zhang; Kai Pan; Yongjie Wang

doi:10.3389/fneur.2024.1348011

Adherence to oxidative balance score is inversely associated with the prevalence of stroke: results from National Health and Nutrition Examination Survey 1999-2018

Front Neurol. 2024 Apr 4:15:1348011. doi: 10.3389/fneur.2024.1348011. eCollection 2024.

Authors

Jiarui Chen¹, Jianjian Liu¹, Zhaowen Gu¹, Jiayong Fan¹, Shuxin Lei¹, Qia Zhang¹, Kai Pan¹, Yongjie Wang^{1

2

3}

Affiliations

¹ The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
² Clinical Research Center for Neurological Diseases of Zhejiang Province, Hangzhou, China.
³ Key Laboratory of Precise Treatment and Clinical Translational Research of Neurological Diseases, Hangzhou, China.

Abstract

Introduction: The relationship between oxidative balance score (OBS), an emerging integrative metric for assessing individual redox homeostasis, and the prevalence of stroke in the general population remains unknown. We aimed to explore these relationships in the National Health and Nutrition Examination Survey (NHANES). We investigated the relationship between the oxidative balance score (OBS) and stroke prevalence using NHANES data from 1999-2018.

Methods: We included eligible individuals from NHANES 1999-2018. OBS calculations were based on previously validated methods, and stroke diagnoses were based on self-reports in questionnaires. Multivariable logistic regression analyses were used to examine the independent associations of overall, dietary, and lifestyle OBS with stroke prevalence. In addition, restricted cubic spline (RCS), stratified analysis, and sensitivity analysis were used.

Results: We included 25,258 participants aged 20-85 years, in which the prevalence of stroke was 2.66%. After adjusting for all confounders, overall and dietary OBS, but not lifestyle OBS, were inversely associated with the prevalence of stroke [odds ratios and 95% confidence intervals of 0.97 (0.96, 0.99) and 0.98 (0.96, 0.99) for overall and dietary OBS, respectively, both p < 0.05]. In addition, there was a dose-response relationship between overall and dietary OBS and stroke prevalence. The RCS showed that these relationships were linear. Stratified analyses indicated that socioeconomic status (SES) significantly influenced the relationship between all OBS and stroke prevalence.

Conclusion: Dietary OBS, but not lifestyle OBS, had an inverse relationship with the prevalence of stroke in the general population. SES significantly influenced the protective effect of OBS against stroke. These findings emphasize the importance of integrated antioxidant properties from diet for stroke prevention.

Keywords: NHANES; oxidative balance score; oxidative stress; prevention; stroke.

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This research was funded by National Natural Science Foundation of China (81502139) and Medical Health Science and Technology Project of Zhejiang Province (2023RC174).