The essential link: How STAT3 connects tumor metabolism to immunity

Shu Zhong; Jingjing Tong

doi:10.1016/j.bbagrm.2024.195028

The essential link: How STAT3 connects tumor metabolism to immunity

Biochim Biophys Acta Gene Regul Mech. 2024 Apr 16;1867(2):195028. doi: 10.1016/j.bbagrm.2024.195028. Online ahead of print.

Authors

Shu Zhong¹, Jingjing Tong²

Affiliations

¹ Hubei Key Laboratory of Genetic Regulation and Integrative Biology, School of Life Sciences, Central China Normal University, Wuhan 430079, PR China.
² Hubei Key Laboratory of Genetic Regulation and Integrative Biology, School of Life Sciences, Central China Normal University, Wuhan 430079, PR China. Electronic address: tongjj@mail.ccnu.edu.cn.

PMID: 38636823
DOI: 10.1016/j.bbagrm.2024.195028

Abstract

Immunotherapy is a promising and long-lasting tumor treatment method, but it is challenged by the complex metabolism of tumors. To optimize immunotherapy, it is essential to further investigate the key proteins that regulate tumor metabolism and immune response. STAT3 plays a crucial role in regulating tumor dynamic metabolism and affecting immune cell function by responding to various cytokines and growth factors, which can be used as a potential target for immunotherapy. This review focuses on the crosstalk between STAT3 and tumor metabolism (including glucose, lipid, and amino acid metabolism) and its impact on the differentiation and function of immune cells such as T cells, tumor-associated macrophages (TAMs), and myeloid-derived suppressor cells (MDSCs), and reveals potential treatment strategies.

Keywords: Immune cell; Immunotherapy; Metabolism; STAT3; Tumor.

Publication types

Review