Discordant Molecular Imaging Findings with 2-[18F]FDG and [68Ga]Ga-PSMA PET/CT in a Patient with Both Bladder and Prostate Cancer

Aparna Mahalik; Jasim Jaleel; Sambit Sagar; Dikhra Khan; Shobhana Raju; Rakesh Kumar

doi:10.1007/s13139-024-00839-4

Discordant Molecular Imaging Findings with 2-[¹⁸F]FDG and [⁶⁸Ga]Ga-PSMA PET/CT in a Patient with Both Bladder and Prostate Cancer

Nucl Med Mol Imaging. 2024 May;58(3):150-151. doi: 10.1007/s13139-024-00839-4. Epub 2024 Jan 29.

Authors

Aparna Mahalik¹, Jasim Jaleel¹, Sambit Sagar¹, Dikhra Khan¹, Shobhana Raju¹, Rakesh Kumar¹

Affiliation

¹ Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, 110029 India.

PMID: 38633286
PMCID: PMC11018560 (available on 2025-05-01)
DOI: 10.1007/s13139-024-00839-4

Abstract

The prevalence of double primary prostate and bladder cancer is not uncommon. Though both share a common pathway of malignant transformation, they bear to differ in the case of 2-[¹⁸F]FDG PET/CT and [⁶⁸Ga]Ga-PSMA uptake. We present a case of double primary cancer involving the bladder and prostate, where the prostatic primary showed intense [⁶⁸Ga]Ga-PSMA uptake with non-avid skeletal and pulmonary metastases, which showed intense 2-[¹⁸F]FDG uptake, thus showing discordance due to different clonal origins.

Keywords: 2-[18F]FDG PET/CT; Prostate cancer; Tumor biology; Urinary bladder cancer; [68Ga]Ga-PSMA PET/CT; [99mTc]Tc-MDP bone scan.