Ocular complications of SAVI: A unique case of bilateral uveitis and retinal vasculitis

Matteo Menean; Alessandro Marchese; Giulio Modorati; Rosa Favale; Francesco Boscia; Francesco Bandello; Elisabetta Miserocchi

doi:10.1016/j.ajoc.2024.102046

Ocular complications of SAVI: A unique case of bilateral uveitis and retinal vasculitis

Am J Ophthalmol Case Rep. 2024 Apr 10:34:102046. doi: 10.1016/j.ajoc.2024.102046. eCollection 2024 Jun.

Authors

Matteo Menean^{1

2}, Alessandro Marchese^{1

2}, Giulio Modorati^{1

2}, Rosa Favale³, Francesco Boscia³, Francesco Bandello^{1

2}, Elisabetta Miserocchi^{1

2}

Affiliations

¹ Division of Head and Neck, Ophthalmology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
² School of Medicine, Vita-Salute San Raffaele University, Milan, Italy.
³ Department of Ophthalmology and Translational Biomedicine and Neurosciences (DiBraiN), University of Bari, Bari, Italy.

Abstract

Purpose: To describe a case of bilateral panuveitis in a patient with Stimulator of Interferon Genes (STING)-Associated Vasculitis with Onset in Infancy (SAVI).

Observations: A 45-year-old patient diagnosed with SAVI presented bilateral panuveitis and uncontrolled secondary intraocular hypertension due to structural complications from uveitis. Multimodal imaging revealed the presence of intraretinal fluid and bilateral vasculitis. The patient was started with systemic methotrexate.

Conclusions and importance: This case is essential to characterize ocular involvement in patients with SAVI. Awareness of these ocular manifestations is crucial for timely management and improvement of visual prognosis.

Keywords: Interferonopathy; SAVI; STING; Uveitis; Vasculitis.

Publication types

Case Reports