Dihydrostilbenes from Macaranga javanica (Blume) Müll. Arg. and their antiplasmodial activity

Tjitjik Srie Tjahjandarie; Muhammad Fajar Aldin; Ratih Dewi Saputri; Mulyadi Tanjung

doi:10.1080/14786419.2024.2342555

Dihydrostilbenes from Macaranga javanica (Blume) Müll. Arg. and their antiplasmodial activity

Nat Prod Res. 2024 Apr 17:1-7. doi: 10.1080/14786419.2024.2342555. Online ahead of print.

Authors

Tjitjik Srie Tjahjandarie¹, Muhammad Fajar Aldin¹, Ratih Dewi Saputri², Mulyadi Tanjung¹

Affiliations

¹ Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya, Indonesia.
² Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Surabaya, Surabaya, Indonesia.

PMID: 38629185
DOI: 10.1080/14786419.2024.2342555

Abstract

An undescribed dihydrostilbene, macajavanicin D (1), and three known analogs, malayheyneiin A (2) and laevifolins A-B (3-4), were isolated from Macaranga javanica (Blume) Müll. Arg. leaves. Macajavanicin D (1) structure was determined based on a combination of ESI-HRMS data and NMR spectra. Compounds 1-4 were evaluated to Plasmodium falciparum strain 3D7. Macajavanicins D (1) and laevifolin A (3) showed potent activity with an IC₅₀ value of 0.85 and 1.03 µg/mL, respectively.

Keywords: Macajavanicin D; Macaranga javanica; antiplasmodial; dihydrostilbene.