Computed Tomography-Based Body Composition is Related to Perioperative Morbidity in Older Lung Transplant Recipients

Daria Kifjak; Helmut Prosch; Stefan Schwarz; Peter Jaksch; Michael Weber; Konrad Hoetzenecker; Thomas Schweiger

doi:10.1055/s-0044-1782683

Computed Tomography-Based Body Composition is Related to Perioperative Morbidity in Older Lung Transplant Recipients

Thorac Cardiovasc Surg. 2024 Apr 16. doi: 10.1055/s-0044-1782683. Online ahead of print.

Authors

Daria Kifjak^{1

2}, Helmut Prosch¹, Stefan Schwarz³, Peter Jaksch³, Michael Weber¹, Konrad Hoetzenecker³, Thomas Schweiger³

Affiliations

¹ Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Wien, Wien, Austria.
² Department of Radiology, UMass Memorial Medical Center and University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States.
³ Department of Thoracic Surgery, Medical University of Vienna, Wien, Wien, Austria.

PMID: 38626904
DOI: 10.1055/s-0044-1782683

Abstract

Background: In older patients, a limited physical reserve is considered a contraindication for lung transplantation (LTx). Herein, we aimed to establish a computed tomography (CT)-based quantification of physical reserve in older patients scheduled for transplantation.

Methods: This retrospective study included patients older than 60 years who received LTx. Semiautomatic measurements of the mediastinal fat area and the dorsal muscle group area in pretransplantation CT scans were performed, and normalized data were correlated with clinical parameters.

Results: Patients (n = 108) were assigned into three groups (Muscle^highfat^low [n = 25], Muscle^lowfat^high [n = 24], and other combinations [n = 59]). The Muscle^lowfat^high group had a significantly increased risk of wound infections (p = 0.002) and tracheostomy (p = 0.001) compared with Muscle^highfat^low patients. The median length of intensive care unit stay (25 vs. 3.5 days; p = 0.002) and the median length of hospital stay (44 vs. 22.5 days; p = 0.013) post-LTx were significantly prolonged in the Muscle^lowfat^high group. Significantly more patients in this group had a prolonged ventilation time (11 vs. 0; p < 0.001).

Conclusion: Body composition parameters determined in pretransplant chest CT scans in older LTx candidates might aid in identifying high-risk patients with a worse perioperative outcome after LTx.

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