Preparation of pH-sensitive porous polylactic acid-based medical dressing with self-pumping function

Zijian Zhang; Jianyong Li; Yi Wang; Xiaojie Wang; Liming Wang; Yinghua Qiu; Fangyi Li; Jianfeng Li; Maocheng Ji; Jia Man

doi:10.1016/j.ijbiomac.2024.131563

Preparation of pH-sensitive porous polylactic acid-based medical dressing with self-pumping function

Int J Biol Macromol. 2024 Apr 16;267(Pt 2):131563. doi: 10.1016/j.ijbiomac.2024.131563. Online ahead of print.

Authors

Zijian Zhang¹, Jianyong Li², Yi Wang³, Xiaojie Wang⁴, Liming Wang¹, Yinghua Qiu¹, Fangyi Li¹, Jianfeng Li¹, Maocheng Ji¹, Jia Man⁵

Affiliations

¹ Key Laboratory of High Efficiency and Clean Mechanical Manufacture, Ministry of Education, School of Mechanical Engineering, Shandong University, Jinan 250061, China; National Demonstration Center for Experimental Mechanical Engineering Education, Shandong University, Jinan 250061, China.
² Key Laboratory of High Efficiency and Clean Mechanical Manufacture, Ministry of Education, School of Mechanical Engineering, Shandong University, Jinan 250061, China; National Demonstration Center for Experimental Mechanical Engineering Education, Shandong University, Jinan 250061, China. Electronic address: ljy@sdu.edu.cn.
³ Department of Dermatology, Central Hospital Affiliated to Shandong First Medical University, Jinan 250013, China. Electronic address: wangyi_sdfmu@hotmail.com.
⁴ Key Laboratory of High Efficiency and Clean Mechanical Manufacture, Ministry of Education, School of Mechanical Engineering, Shandong University, Jinan 250061, China; Department of Pharmacology, School of Basic Medical Sciences, Shandong University, Jinan 250012, China.
⁵ Key Laboratory of High Efficiency and Clean Mechanical Manufacture, Ministry of Education, School of Mechanical Engineering, Shandong University, Jinan 250061, China; National Demonstration Center for Experimental Mechanical Engineering Education, Shandong University, Jinan 250061, China. Electronic address: mj@sdu.edu.cn.

PMID: 38626837
DOI: 10.1016/j.ijbiomac.2024.131563

Abstract

Excessive exudation from the wound site and the difficulty of determining the state of wound healing can make medical management more difficult and, in extreme cases, lead to wound deterioration. In this study, we fabricated a pH-sensitive colorimetric chronic wound dressing with self-pumping function using electrostatic spinning technology. It consisted of three layers: a polylactic acid-curcumin (PCPLLA) hydrophobic layer, a hydrolyzed polyacrylonitrile (HPAN) transfer layer, and a polyacrylonitrile-purple kale anthocyanin (PAN-PCA) hydrophilic layer. The results showed that the preparation of porous PLLA fiber membrane loaded with 0.2 % Cur was achieved by adjusting the spinning-related parameters, which could ensure that the composite dressing had sufficient anti-inflammatory, antibacterial and antioxidant properties. The HPAN membrane treated with alkali for 30 min had significantly enhanced liquid wetting ability, and the unidirectional transport of liquid could be achieved by simple combination with the 20 um PCPLLA fiber membrane. In addition, the 4 % loaded PCA showed more obvious color difference than the colorimetric membrane. In vivo and ex vivo experiments have demonstrated the potential of multifunctional dressings for the treatment of chronic wounds.

Keywords: Porous fiber; Self-pumping; pH-sensitive.