Ophthalmologic profile of patients with systemic sclerosis

Sandeep Choudhary; Arghya Chattopadhyay; Pankaj Gupta; Aditi Mehta; Siddharth Jain; Sanghamitra Machhua; Ranjana W Minz; Reema Bansal; Shobha Sehgal; Surinder S Pandav; Shefali K Sharma

doi:10.4103/IJO.IJO_2980_23

Ophthalmologic profile of patients with systemic sclerosis

Indian J Ophthalmol. 2024 Apr 16. doi: 10.4103/IJO.IJO_2980_23. Online ahead of print.

Affiliations

¹ Department of Ophthalmology, Advanced Eye Center, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
² Department of Internal Medicine, Rheumatology Services, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
³ Department of Immunopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

PMID: 38622854
DOI: 10.4103/IJO.IJO_2980_23

Abstract

Purpose: To study the ophthalmologic manifestations of systemic sclerosis (SSc) and its correlation with autoantibody profile.

Methods: A cross-sectional study on 200 eyes of 100 consecutive adult patients diagnosed with SSc was performed at a tertiary care center in Northern India. The examination of ocular adnexa, anterior segment, and posterior segment with slit-lamp biomicroscopy, tear film break-up time (TBUT), Schirmer's II test, and choroidal thickness measurement by swept-source ocular coherence tomography was done. Autoantibody profile was available for 85 patients, and its statistical association with the ocular examination findings was analyzed.

Results: In total, 100 patients (93 females and 7 males) were included. The mean age was 45.11 ± 11.68 years, and the mean disease duration was 6.93 ± 3.68 years. Meibomian gland disease was more commonly found in patients with the diffuse subtype of SSc (P = 0.037). Choroidal thickness was increased in 34% and decreased in 7% (reference range = 307 ± 79 mm) patients. Reduced TBUT, meibomian gland dysfunction, and eyelid stiffness had a statistically significant association with the presence of anti-Scl-70 antibody (P = 0.003, <0.0001, and 0.004, respectively). These patients had ocular fatigue, foreign body sensation, and burning sensation. No significant association was noted with the presence of SS-A/Ro and SS-B/La antibodies.

Conclusion: This study highlights the need for an active comprehensive ophthalmic evaluation. Approximately 75% of the patients in our cohort had ocular involvement to varying extent. An isolated presence of anti-Scl70 antibody was also found to have a positive association with dry eye disease.