The research history, hot spots and frontier trends of acupuncture and moxibustion for Alzheimer's disease (AD) were explored using knowledge graph technology. The articles on acupuncture and moxibustion for AD were searched from 6 databases, i.e. CNKI, VIP, Wanfang, SinoMed, Pubmed and Web of Science, from January 1st, 1993 to January 1st, 2023. Using CiteSpace6.2.R2 Advance and VOSviewer V1.6.19 softwares, the knowledge map was graphed and the visual analysis was performed. A total of 1 228 Chinese and 309 English articles were included. The high-frequency keywords were generally divided into the keywords of clinical diseases (AD, dementia), those of therapeutic methods (electroacupuncture, acupuncture-moxibustion and acupuncture) and those of mechanism study (β-amyloid, mice). Thirteen keyword clusters were formed among the articles of Chinese version, e.g. acupuncture-moxibustion, dementia, acupuncture and electroacupuncture; and 8 clusters were obtained among English articles, e.g. electroacupuncture, drug therapy and hippocampus. The high-frequency keywords of acupoints included Baihui (GV 20), Dazhui (GV 14), Yintang (GV 24+), Zusanli (ST 36), Fenglong (ST 40), etc. Six clusters of "acupuncture techniques → acupoints" were obtained for the treatment of AD with acupuncture and moxibustion. The therapeutic methods and modes of AD with acupuncture and moxibustion are constantly progressed, the development of clinical research tends to the evaluation of novel therapeutic mode and clinical effect, and the mechanism of acupuncture and moxibustion for the effect on AD are more deeply explored. Among the various therapeutic methods, acupuncture-moxibustion, acupuncture and electroacupuncture have been early predominant; while, many novel methods are gradually displayed later, such as music electroacupuncture and hydro-acupuncture. In recent 30 years, among Chinese and English articles for the studies of AD treated with acupuncture and moxibustion, the theme of them focuses on the two aspects, the observation of clinical effect and the mechanism research. It is found that the clinical therapeutic methods have been gradually improved and the mechanism exploration been deepened.
基于知识图谱技术探究针灸治疗阿尔茨海默病的研究历程、热点和前沿趋势。检索中国期刊全文数据库（CNKI）、维普资讯中文期刊服务平台（VIP）、万方数据知识服务平台（Wanfang）、中国生物医学文献数据库 （SinoMed）、PubMed、Web of Science 6个数据库1993年1月1日至2023年1月1日收录的针灸治疗阿尔茨海默病的文献，运用CiteSpace6.2.R2 Advance、VOSviewer V1.6.19软件绘制知识图谱并进行可视化分析。共纳入中文文献1 228篇、英文文献309篇。高频关键词大致分为临床疾病关键词（阿尔茨海默病、老年痴呆）、治疗方式关键词（电针、针灸、针刺）及作用机制研究关键词（β-淀粉样蛋白、小鼠）。中文文献形成了13个关键词聚类（针灸、老年痴呆、针刺、电针等），英文文献形成了8个关键词聚类（电针、药物治疗、海马等）。高频腧穴关键词为百会、大椎、印堂、足三里、丰隆等。总结出针灸治疗AD相关“针法-穴位”聚类6个。针灸治疗AD的治法及治疗模式不断发展，临床研究趋势逐渐向新型治疗方式及临床疗效评价方面发展，针灸治疗AD作用机制研究更加深入。在各种治疗方式中，针灸、针刺、电针等治疗方式主流时间较早，音乐电针、水针等多种新型治疗方式逐渐展现。近30年来，针灸治疗阿尔茨海默病中英文文献研究主题主要集中在临床疗效观察及作用机制研究两个方面，临床治疗方式逐渐完善，作用机制的探索逐渐深入。.
Keywords: Alzheimer's disease; acupuncture and moxibustion; bibliometrics; knowledge graph.