Objectives: This systematic review and meta-analysis aims to investigate the effectiveness of left subclavian artery revascularization compared to non-revascularization in thoracic endovascular aortic repair, and to summarize the current evidence on its indications.
Methods: A computerized search was conducted across multiple databases, including MEDLINE, SCOPUS, Cochrane Library, and Web of Science, for studies published up to November 2023. Study selection, data abstraction, and quality assessment (using the Newcastle-Ottawa Scale) were independently conducted by two reviewers, with a third author resolving discrepancies. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using random-effects models and publication bias was assessed using funnel plots.
Results: In the 76 included studies, left subclavian artery revascularization was associated with reduced risks of stroke (OR, 0.67; 95% CI, 0.45-0.98; n=15331), spinal cord ischemia (OR, 0.75; 95% CI, 0.56-0.99; n=11995), and arm ischemia (OR, 0.09; 95% CI, 0.01-0.59; n=8438). No significant reduction in paraplegia (OR, 0.56; 95% CI, 0.21-1.47; n=1802) or mortality (OR, 0.77; 95% CI, 0.53-1.12; n=11831) was observed. Moreover, the risk of endoleak was comparable in both groups (OR, 1.25; 95% CI, 0.55-2.84; p=0.60; n=793), whereas the risk of reintervention was significantly higher in the revascularization group (OR, 1.98; 95% CI, 1.03-3.83; p=0.04; n=272). Both groups had similar risks of major (OR, 0.45; 95% CI, 0.19-1.09; p=0.08; n=1113), minor (OR, 0.21; 95% CI, 0.01-3.45; p=0.27; n=183), renal (OR, 0.61; 95% CI, 0.12-3.06; p=0.55; n=310), and pulmonary (OR, 0.59; 95% CI, 0.16-2.15; p=0.42; n=8083) complications. The most frequent indications for left subclavian artery revascularization were primary prevention of spinal cord ischemia, augmentation of the landing zone, and primary stroke prevention.
Conclusions: Left subclavian artery revascularization in thoracic endovascular aortic repair was associated with reduced neurological complications but was not found to impact mortality. The study highlights important indications for revascularization as well as significant predictors of complications, providing a basis for clinical decision-making and future research.
Keywords: arm ischemia; left subclavian artery revascularization; spinal cord ischemia; stroke; thoracic endovascular aortic repair.
Copyright © 2024. Published by Elsevier Inc.