Natural medicinal plant products as an immune-boosters: A possible role to lessen the impact of Covid-19

Abstract

Transmissible Covid-19, caused by novel corona virus since last of 2019 has outspread widely until now. Where, India was the second most affected country and 3rd in mortality rate. In world ancient history, medicinal plants were played a crucial role to cure several diseases. In present study, we show some novel natural medicinal plant metabolites as the potential inhibitors against papain-like protease (PLpro), main protease (Mpro) and RNA-dependent RNA polymerase (RdRp), transmembrane proteinase Serine 2 (TMPRSS2) and angiotensin converting enzyme-2 (ACE-2) of Covid-19. Plant metabolites were having been proven to inhibit SARS-CoVs, which also actively walkable against Covid-19.

Keywords: ACE-2, angiotensin converting enzyme-2; CSG, Coronavirus Study Group; Covid-19; Covid-19, corona virus disease-2019; E, small envelope protein; IC, Inhibitory concentration; ICTV, International Committee on Taxonomy of Viruses; M, matrix protein; Medicinal plant; Mpro, main protease; N, nucleocapsid protein; PLpro, papain-like protease; Plant metabolites; RBD, receptor binding domain; RdRp, RNA-dependent RNA polymerase; S, spike protein; SARS-CoV; ST, swine testicular; TMPRSS2, transmembrane proteinase Serine 2; WHO, world health organization; nsps, non-structural proteins.