Solubility, Thermodynamic Parameters, and Dissolution Properties of 17-α Hydroxyprogesterone in 13 Pure Solvents

Qi Zhao; Yinhu Pan; Yankai Xiong; Ping Xu; Qianyun Sun; Hemei Yin; Fumin Xue

doi:10.1021/acsomega.3c09922

Solubility, Thermodynamic Parameters, and Dissolution Properties of 17-α Hydroxyprogesterone in 13 Pure Solvents

ACS Omega. 2024 Mar 31;9(14):16106-16117. doi: 10.1021/acsomega.3c09922. eCollection 2024 Apr 9.

Authors

Qi Zhao¹, Yinhu Pan², Yankai Xiong³, Ping Xu¹, Qianyun Sun⁴, Hemei Yin¹, Fumin Xue¹

Affiliations

¹ School of Pharmaceutical Sciences, Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, P. R. China.
² School of Material Science and Engineering, Shandong Jianzhu University, Jinan 250101, P. R. China.
³ Shandong Provincial Center for Solid Waste and Hazardous Chemical Pollution Control, Jinan 250014, P. R. China.
⁴ Shandong Institute of Metrology, Jinan 250014, P. R. China.

Abstract

The static gravimetric method was used to measure the solubility of 17-α hydroxyprogesterone (OHP) in 13 pure solvents ranging from 278.15 to 323.15 K. The results indicate that the experimental solubility of OHP increases with increasing temperature. The experimental solubility data were correlated by the selected van't Hoff model, λh model, modified Apelblat model, Yaws model, and nonrandom two-liquid (NRTL) model. The fitting results show that the Yaws model can give better correlation results by fitting 13 different pure solvent systems. Based on the NRTL equation, the thermodynamic analysis of solubility data showed that the mixing process was spontaneous. The Hansen solubility parameters (HSPs) and solvent effect were applied to explore these solubility characteristics. Finally, the thermodynamic properties Δ_solH°, Δ_solS°, Δ_solG°, %ξ_H, and %ξ_TS were calculated by the van't Hoff model equation. The results showed that Δ_solH°, Δ_solS°, and Δ_solG° are all positive values, indicating that the dissolution of OHP in the selected solvent is an endothermic reaction with increasing entropy.