Revealing the mechanism of central pain hypersensitivity in primary dysmenorrhea: evidence from neuroimaging

Ping Jin; Fangli Wang; Fanfan Zeng; Jing Yu; Feng Cui; Bingkui Yang; Luping Zhang

doi:10.21037/qims-23-1687

Revealing the mechanism of central pain hypersensitivity in primary dysmenorrhea: evidence from neuroimaging

Quant Imaging Med Surg. 2024 Apr 3;14(4):3075-3085. doi: 10.21037/qims-23-1687. Epub 2024 Mar 28.

Authors

Ping Jin^#¹, Fangli Wang^#², Fanfan Zeng³, Jing Yu², Feng Cui¹, Bingkui Yang¹, Luping Zhang¹

Affiliations

¹ Department of Radiology, Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, China.
² Department of Acupuncture and Moxibustion, Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, China.
³ Department of Ultrasound, Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, China.

^# Contributed equally.

Abstract

Background: Primary dysmenorrhea (PDM) is the most common problem in menstruating women. A number of functional magnetic resonance imaging (fMRI) study have revealed that the brain plays a crucial role in the pathophysiology of PDM. However, these results have been inconsistent, and there is a lack of a comprehensive fMRI study to clarify the onset and long-term effects of PDM. The aim of this study was thus to investigate the onset and long-term effects of PDM in a cohort of patients with PDM.

Methods: This study employed a cross-sectional design with prospective data collection, in which 25 patients with PDM and 20 healthy controls (HCs) were recruited. The patients with PDM underwent fMRI scans both during the PDM during the pain phase (PDM-P) and nonpain phase (PDM-NP). The long-term effects of PDM on the brain was assessed by comparing PDM-NP findings with those of HCs, and the central mechanism of PDM was assessed by comparing the PDM-P findings with those of PDM-NP. To identify changes in brain function, the amplitude of low-frequency fluctuations and the regional homogeneity (ReHo) were measured. To assess changes in brain structure, voxel-based morphometry (VBM) was applied. The periaqueductal gray (PAG) was set as a region of for conducting seed-based whole-brain functional connectivity (FC) analysis. Subsequently, Pearson correlation analyses were employed to evaluate the associations between the abnormal brain region and the clinical information of the patients.

Results: There were neither functional nor structural differences between patients in the PDM-NP and HCs. Compared with those in PDM-NP, those in PDM-P showed increased ReHo in the left dorsolateral prefrontal cortex (DLPFC) but decreased FC between PAG and right superior parietal gyrus, bilateral inferior parietal gyrus, right calcarine gyrus, left superior occipital gyrus, left precentral gyrus, right DLPFC, and left crus I of the cerebellar hemisphere.

Conclusions: The results from this study suggest that the mechanism of central pain hypersensitivity of PDM may be related to the disorder of the FC between the PAG and descending pain modulation system, default mode network (DMN), and occipital lobe. These findings could help us better understand the pathophysiology of PDM from a neuroimaging perspective.

Keywords: Functional magnetic resonance imaging (fMRI); functional connectivity (FC); pain modulatory system; primary dysmenorrhea (PDM); regional homogeneity (ReHo).