Tumid Lupus Erythematosus (TLE): A Review of a Rare Variant of Chronic Cutaneous Lupus Erythematosus (cCLE) with Emphasis on Differential Diagnosis

Maged Daruish; Francesca Ambrogio; Caterina Foti; Alessandra Filosa; Gerardo Cazzato

doi:10.3390/diagnostics14070780

Tumid Lupus Erythematosus (TLE): A Review of a Rare Variant of Chronic Cutaneous Lupus Erythematosus (cCLE) with Emphasis on Differential Diagnosis

Diagnostics (Basel). 2024 Apr 8;14(7):780. doi: 10.3390/diagnostics14070780.

Authors

Maged Daruish¹, Francesca Ambrogio², Caterina Foti², Alessandra Filosa³, Gerardo Cazzato⁴

Affiliations

¹ Dorset County Hospital NHS Foundation Trust, Dorchester DT1 2JY, UK.
² Section of Dermatology and Venereology, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), University of Bari "Aldo Moro", 70124 Bari, Italy.
³ Pathology Department, "A. Murri" Hospital-ASUR Marche, Aree Vaste n. 4 and 5, 63900 Fermo, Italy.
⁴ Section of Molecular Pathology, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), University of Bari "Aldo Moro", 70124 Bari, Italy.

Abstract

Tumid lupus erythematosus (TLE) has been the subject of heated debate regarding its correct nosographic classification. The definition of TLE has changed over time, varying according to the different studies performed. In this review, we address the initial definition of TLE, the changes that have taken place in the understanding of TLE, and its placement within the classification of cutaneous lupus erythematosus (CLE), with a focus on clinical, histopathological, immunophenotypical, and differential diagnosis aspects.

Keywords: TLE; cCLE; inflammatory dermatopathology; systemic lupus erythematosus; tumid lupus erythematosus.

Publication types

Review

Grants and funding

This research received no external funding.