Modulation of immune responses in the central nervous system by Zika virus, West Nile virus, and dengue virus

Shuhui Wu; Ting Zhang; Weidong Qiang; Yang Yang

doi:10.1002/rmv.2535

Modulation of immune responses in the central nervous system by Zika virus, West Nile virus, and dengue virus

Rev Med Virol. 2024 May;34(3):e2535. doi: 10.1002/rmv.2535.

Authors

Shuhui Wu^{1

2}, Ting Zhang², Weidong Qiang², Yang Yang³

Affiliations

¹ Department of Clinical Laboratory, Zhumadian Central Hospital, Affiliated Hospital of Huanghuai University, Zhumadian, China.
² School of Medicine Huanghuai University, Zhumadian, China.
³ Department Neurosurgery, Zhumadian Central Hospital, Affiliated Hospital of Huanghuai University, Zhumadian, China.

PMID: 38610091
DOI: 10.1002/rmv.2535

Abstract

Arthropod-borne viruses (arboviruses) pose significant threats to global public health by causing a spectrum of diseases ranging from mild febrile illnesses to severe neurological complications. Understanding the intricate interplay between arboviruses and the immune system within the central nervous system is crucial for developing effective strategies to combat these infections and mitigate their neurological sequelae. This review comprehensively explores the mechanisms by which arboviruses such as Zika virus, West Nile virus, and Dengue virus manipulate immune responses within the CNS, leading to diverse clinical manifestations.

Keywords: West Nile virus; Zika virus; dengue virus; immune response.

Publication types

Review

MeSH terms

Central Nervous System
Dengue Virus*
Humans
Immunity
West Nile virus*
Zika Virus Infection* / complications
Zika Virus*