Diaporchalasins A-E, New Cytochalasins from the Endophytic Fungus Diaporthe sp. BMX12 Isolated from Aquilaria sinensis

Li Yang; Qi Wang; Qing-Yun Ma; Qing-Yi Xie; Cui-Juan Gai; You-Gen Wu; Hao-Fu Dai; You-Xing Zhao

doi:10.1002/cbdv.202400567

Diaporchalasins A-E, New Cytochalasins from the Endophytic Fungus Diaporthe sp. BMX12 Isolated from Aquilaria sinensis

Chem Biodivers. 2024 Apr 11:e202400567. doi: 10.1002/cbdv.202400567. Online ahead of print.

Authors

Li Yang¹, Qi Wang¹, Qing-Yun Ma¹, Qing-Yi Xie¹, Cui-Juan Gai¹, You-Gen Wu², Hao-Fu Dai¹, You-Xing Zhao¹

Affiliations

¹ Key Laboratory of Research and Development of Natural Product from Li Folk Medicine of Hainan Province & National Key Laboratory for Tropical Crop Breeding, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, Hainan, 571101, China.
² Sanya Nanfan Research Institute, Hainan University, Sanya, 572025, China.

PMID: 38602253
DOI: 10.1002/cbdv.202400567

Abstract

Five new cytochalasins, diaporchalasins A-E (1-5), together with 14 known congeners (6-19) were isolated from the endophytic fungus Diaporthe sp. BMX12, which was isolated from the branches of Aquilaria sinensis. The structures of the new compounds were elucidated by extensive spectroscopic analyses including high-resolution electron spray ionization mass spectrometry (HR-ESI-MS) and nuclear magnetic resonance (NMR). Their absolute configurations were assigned by theoretical electronic circular dichroism (ECD) calculations. Compounds 11 and 12 featuring a keto carbonyl at C-21 displayed cytotoxicity toward K562, BEL-7402, SGC-7901, A549, and HeLa cell lines with IC₅₀ values ranging from 4.4 to 47.4 μM.

Keywords: Cytochalasin; Cytotoxicity; Diaporthe sp.; Endophytic fungus.

Abstract

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