Sesquiterpenoids from the roots of Lindera glauca and their cytotoxicity activities

Fanrong Zeng; Xinyuan Pan; Xiongyu Meng; Qing Li; Huaqiang Li

doi:10.1093/bbb/zbae045

Sesquiterpenoids from the roots of Lindera glauca and their cytotoxicity activities

Biosci Biotechnol Biochem. 2024 Apr 10:zbae045. doi: 10.1093/bbb/zbae045. Online ahead of print.

Authors

Fanrong Zeng¹, Xinyuan Pan², Xiongyu Meng², Qing Li³, Huaqiang Li²

Affiliations

¹ The Disease Control and Prevention Laboratory Center of Tongnan District, Chongqing, China.
² School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, China.
³ Department of Pharmacy, The 904th Hospital of Joint Logistic Support Force of PLA, Changzhou, China.

PMID: 38599635
DOI: 10.1093/bbb/zbae045

Abstract

The chemical investigation of the roots of Lindera glauca guided the isolation and identification of three new sesquiterpenoids, namly glaucatotones J-L (1-3), and one known congener, (1β,5β)-1-hydroxyguaia-4(15),11(13)-dieno-12,5-lactone (4). The structures of new compounds were established based on comprehensive spectrographic methods, mainly including 1D & 2D NMR and HRESIMS analyses, and the absolute configurations were further confirmed by the comparison of experimental and calculated electronic circular dichroism (ECD). The cytotoxicity activities of isolates were evaluated, and the results showed that they have moderate cytotoxic activities.

Keywords: Lindera glauca; cytotoxicity; norsesquiterpenoids; sesquiterpenoids.