Assessment of Platelet-Rich Plasma Alone and Platelet-Rich Plasma Combined with Bioactive Glass in the Management of Intrabony Defect

Anuj Singh Parihar; Reghunathan S Preethanath; Nubesh Khan; Abhijita Mohapatra; Arunima Padmakumar Reshma; Pavithra Rangarajan Seshadri; Minal Vaibhav Awinashe

doi:10.4103/jpbs.jpbs_1100_23

Assessment of Platelet-Rich Plasma Alone and Platelet-Rich Plasma Combined with Bioactive Glass in the Management of Intrabony Defect

J Pharm Bioallied Sci. 2024 Feb;16(Suppl 1):S933-S935. doi: 10.4103/jpbs.jpbs_1100_23. Epub 2024 Feb 29.

Authors

Anuj Singh Parihar¹, Reghunathan S Preethanath², Nubesh Khan³, Abhijita Mohapatra⁴, Arunima Padmakumar Reshma⁵, Pavithra Rangarajan Seshadri⁶, Minal Vaibhav Awinashe⁷

Affiliations

¹ Reader, Department of Periodntology, People's Dental Academy, Bhopal, Madhya Pradesh, India.
² Associate Professor, Department of Preventive Dental Sciences, College of Dentistry, Jazan University, Saudi Arabia.
³ Assistant Professor, Department of Preventive Dentistry, College of Dentistry in Ar Rass, Qassim University, Al-Qassim, Kingdom of Saudi Arabia.
⁴ Professor, Department of Prosthodontics, Institute of Dental Sciences, SOA University, Bhubaneswar, Odisha, India.
⁵ Professor, Department of Periodontics and Implantology, PMS College of Dental Sciences and Research, Thiruvananthapuram, Kerala, India, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamil Nadu, India.
⁶ Reader, Department of Periodontics, Ragas Dental College and Hospital, Uthandi, Chennai, Tamil Nadu, India.
⁷ Oral and maxillofacial Pathology, Assistant Professor, Department of Oral Surgery And Diagnostic Sciences, College Of Dentistry, Qassim University, Buraidah, Kingdom of Saudi Arabia.

Abstract

Objectives: To assess the function of platelet-rich plasma (PRP) both only and in combination with bioactive glass in intrabony defects.

Materials and method: Twenty patients were split into two groups with 10 samples each: group I with PRP alone, whereas group II was done with PRP in addition to bioactive glass. Following local anesthesia, full-thickness mucoperiosteal flaps were elevated in the afflicted site, the defect was debrided, and root planning with curettes was performed. Irrigation was then used while in group II- PRP along with bone graft (BG) preservationwas done. Suturing in group I was contained. At day 0 (baseline) and 6 months after surgery, the clinical parameters for probing depth, clinical attachment stage, and radiographic assessment were noted for both groups.

Result: When comparing both groups, there was no statistically considerable variation. However, the intragroup comparison for pocket depth and clinical attachment level between baseline and 6 months was significant. Radiographic bone level was not considerably dissimilar across groups; however, it was significantly different between groups.

Conclusion: Reduced probing depth, higher clinical attachment level, and radiographic evidence of bone fill are clinical outcome measures that are associated with effective regenerative therapy.

Keywords: Bone graft; depth; periodontal; pocket.