Assessment of Role of Bisphosphonates on Dental Implant Treatment in Post-menopausal Ladies

Abhigyan Manas; Munaz Mulla; Shubhi Grover; Mirna Garhnayak; Mushir Mulla; Anuj Singh Parihar

doi:10.4103/jpbs.jpbs_992_23

Assessment of Role of Bisphosphonates on Dental Implant Treatment in Post-menopausal Ladies

J Pharm Bioallied Sci. 2024 Feb;16(Suppl 1):S748-S750. doi: 10.4103/jpbs.jpbs_992_23. Epub 2024 Feb 16.

Authors

Abhigyan Manas¹, Munaz Mulla², Shubhi Grover³, Mirna Garhnayak⁴, Mushir Mulla^{5

6}, Anuj Singh Parihar⁷

Affiliations

¹ Reader, Department of Oral and Maxillofacial Surgery, Maharana Pratap Dental College, Kanpur, Uttar Pradesh, India.
² Department of Periodontolgy, Yenepoya Dental College, Yenepoya University, Mangalore, Karnataka, India.
³ Senior Lecturer, Department of Prosthodontics, Crown and Bridge, Uttaranchal Dental and Medical Research Institute, Dehradun, Uttarakhand, India.
⁴ Professor, Department of Prosthodontics, Institute of Dental Sciences, SOA, University, Bhubaneswar, Odisha, India.
⁵ Department of Public Health Dentistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India.
⁶ Assistant Professor, Department of Oral and Dental Health, College of Applied Health Sciences in Arrass, Qassim University, Saudi Arabia.
⁷ Reader, Department of Periodontology, People's Dental Academy, Bhopal, Madhya Pradesh, India.

Abstract

Objectives: To examine the impact of bisphosphonates (BPs) on dental implant treatment and alveolar bone in post-menopausal ladies.

Materials and methods: Twenty post-menopausal ladies who had at least one dental implant within the previous 5 years participated in the current study. Ten subjects were categorized into two groups: Group A had BP medication for 1.5 years, and group B received parathyroid hormone (PTH). Both groups' bone thickness and bone mineral density (BMD) were measured.

Result: Group A had 5%, and group B had 5% of dental implants failures. BMD of cortical bone was 1468 ± 136 mg/mL and 1008 ± 84 mg/mL in groups A and B, correspondingly. The cortical and cancellous bone densities in both the groups were statically significant. Cortical bone thickness was insignificant in comparison.

Conclusion: Both cortical and cancellous bones' bone mineral density decreased in both groups. With continued usage of BPs, the cortical bone thickness increased.

Keywords: Bisphosphonate; failures; implant; post-menopausal ladies.