Role of ONECUT family transcription factors in cancer and other diseases

Exp Cell Res. 2024 May 1;438(1):114035. doi: 10.1016/j.yexcr.2024.114035. Epub 2024 Apr 7.

Abstract

Members of ONECUT transcription factor play an essential role in several developmental processes, however, the atypical expression of ONECUT proteins lead to numerous diseases, including cancer. ONECUT family proteins promote cell proliferation, progression, invasion, metastasis, angiogenesis, and stemness. This family of proteins interacts with other proteins such as KLF4, TGF-β, VEGFA, PRC2, SMAD3 and alters their expression involved in the regulation of various signaling pathways including Jak/Stat3, Akt/Erk, TGF-β, Smad2/3, and HIF-1α. Furthermore, ONECUT proteins are proposed as predictive biomarkers for pancreatic and gastric cancers. The present review summarizes the involvement of ONECUT family proteins in the development and progression of various human cancers and other diseases.

Keywords: Cancer; Migration; ONECUT; Oncogene; Tumor-suppressor.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Proliferation / genetics
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Kruppel-Like Factor 4*
  • Neoplasms* / genetics
  • Neoplasms* / metabolism
  • Neoplasms* / pathology
  • Signal Transduction
  • Transcription Factors* / genetics
  • Transcription Factors* / metabolism

Substances

  • Kruppel-Like Factor 4
  • KLF4 protein, human
  • Transcription Factors