Effects of 12 weeks of inspiratory muscle training and whole body vibration on the inflammatory profile, BDNF and muscular system in pre-frail elderly women: A randomized controlled trial

Helga Cecília Muniz de Souza; Maíra Florentino Pessoa; Rafaela Dos Santos Clemente; Alanna Vasconcelos da Silva; Pablo Ramon Gualberto Cardoso; Juliana Fernandes; Arméle Dornelas de Andrade

doi:10.1016/j.archger.2024.105421

Effects of 12 weeks of inspiratory muscle training and whole body vibration on the inflammatory profile, BDNF and muscular system in pre-frail elderly women: A randomized controlled trial

Arch Gerontol Geriatr. 2024 Mar 24:123:105421. doi: 10.1016/j.archger.2024.105421. Online ahead of print.

Authors

Helga Cecília Muniz de Souza¹, Maíra Florentino Pessoa², Rafaela Dos Santos Clemente³, Alanna Vasconcelos da Silva³, Pablo Ramon Gualberto Cardoso⁴, Juliana Fernandes⁵, Arméle Dornelas de Andrade⁶

Affiliations

¹ Postgraduate Program of Biology Applied to Health, Federal University of Pernambuco, Recife, Pernambuco, Brazil; Hospital das Clínicas de Pernambuco - Empresa Brasileira de Serviços Hospitalares (HCPE-EBSERH), Federal University of Pernambuco, Recife, Brazil; Laboratory of Cardiopulmonary Physiotherapy, Department of Physiotherapy, Federal University of Pernambuco, Recife, Brazil. Electronic address: helgamuniz@yahoo.com.br.
² Postgraduate Program of Biology Applied to Health, Federal University of Pernambuco, Recife, Pernambuco, Brazil; Laboratory of Cardiopulmonary Physiotherapy, Department of Physiotherapy, Federal University of Pernambuco, Recife, Brazil.
³ Laboratory of Cardiopulmonary Physiotherapy, Department of Physiotherapy, Federal University of Pernambuco, Recife, Brazil.
⁴ Laboratory of Immunomodulation and New Approaches, Federal University of Pernambuco, Recife, Brazil.
⁵ Laboratory of Physiotherapy and Collective Health, Department of Physiotherapy, Federal University of Pernambuco, Recife, Brazil.
⁶ Postgraduate Program of Biology Applied to Health, Federal University of Pernambuco, Recife, Pernambuco, Brazil; Laboratory of Cardiopulmonary Physiotherapy, Department of Physiotherapy, Federal University of Pernambuco, Recife, Brazil. Electronic address: armeledornelas@yahoo.com.

PMID: 38593699
DOI: 10.1016/j.archger.2024.105421

Abstract

Aim: to investigate the effects of the whole body vibration (WBV) and inspiratory muscle training (IMT) on the inflammatory profile and in muscle mass and strength in pre-frail older women.

Methods: this study was a randomized double-blind trial. Forty two older women aged 60-80 years were randomly allocated to IMT + WBV (G1), IMTsham + WBV (G2) or Sham groups (G3). During 12 weeks G1 received both trainings, whereas G2 received WBV alone and G3 received IMT with a low fixed load and were positioned at the vibratory platform without therapeutic effect. Participants were evaluated before and after the intervention for the following outcomes: Brain-derived neurotrophic factor (BDNF) and inflammatory biomarkers (IB), respiratory (RT) and quadriceps thickness (QT) and diaphragmatic mobility (DM) using muscle ultrasound, body composition (BC) using a bioelectrical impedance scale and inspiratory muscle strength (IMS).

Results: after the training, G1 (114.93 ± 21.29) improved IMS (p<0.005) compared with G2 (91.29 ± 23.10) and G3 (85.21 ± 27.02). There was also a significant improve on time of the DM (p<0.001) and RT (p=0.006) for G1 (8.59 ± 3.55 and 11.11 ± 12.66) compared with G2 (1.05 ± 3.09 and 1.10 ± 10.60) and G3 (0.40 ± 2.29 and -1.85 ± 7.45). BDNF, IB, QT and BC were similar between groups.

Conclusions: IMT associated with WBV is effective to improve in increasing IMS, RT and DM in pre-frail older women. However, these interventions do not modify BDNF, IB, QT or BC in this population.

Keywords: Biomarkers; Exercise; Frailty; Muscle mass; Respiratory muscles; Ultrasound.