The association between blood biological age at rehabilitation admission and physical activity during rehabilitation in geriatric inpatients: RESORT

Jessica K Lu; Lihuan Guan; Weilan Wang; Anna G M Rojer; Fedor Galkin; Jorming Goh; Andrea B Maier

doi:10.1007/s11357-024-01152-w

The association between blood biological age at rehabilitation admission and physical activity during rehabilitation in geriatric inpatients: RESORT

Geroscience. 2024 Apr 9. doi: 10.1007/s11357-024-01152-w. Online ahead of print.

Authors

Jessica K Lu^{1

2}, Lihuan Guan^{1

2}, Weilan Wang^{1

2}, Anna G M Rojer³, Fedor Galkin⁴, Jorming Goh^{1

2

5}, Andrea B Maier^{6

7

8}

Affiliations

¹ Centre for Healthy Longevity, National University Health System, Singapore, Singapore.
² Healthy Longevity Translational Research Program, @Age Singapore, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
³ Department of Human Movement Sciences, @AgeAmsterdam, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Van Der Boechorstsraat 7, 1081 BT, Amsterdam, The Netherlands.
⁴ Deep Longevity, Hong Kong, China.
⁵ Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
⁶ Centre for Healthy Longevity, National University Health System, Singapore, Singapore. a.b.maier@vu.nl.
⁷ Healthy Longevity Translational Research Program, @Age Singapore, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. a.b.maier@vu.nl.
⁸ Department of Human Movement Sciences, @AgeAmsterdam, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Van Der Boechorstsraat 7, 1081 BT, Amsterdam, The Netherlands. a.b.maier@vu.nl.

PMID: 38589672
DOI: 10.1007/s11357-024-01152-w

Abstract

Geriatric rehabilitation inpatients have high levels of sedentary behaviour (SB) and low levels of physical activity (PA). Biological age predicted by blood biomarkers is indicative of adverse outcomes. The objective was to determine the association between blood biological age at rehabilitation admission and levels of SB and PA during rehabilitation in geriatric inpatients. Inpatients admitted to geriatric rehabilitation wards at the Royal Melbourne Hospital (Melbourne, Australia) from October 22, 2019, to March 29, 2020, in the REStORing health of acute unwell adulTs (RESORT) observational cohort were included. Blood biological age was predicted using SenoClock-BloodAge, a hematological ageing clock. Patients wore an inertial sensor to measure SB and PA. Logistic regression analyses were conducted. A total of 111 patients (57.7% female) with mean age 83.3 ± 7.5 years were included in the analysis. The mean blood biological age was 82.7 ± 8.4 years. Patients with 1-year higher blood biological age had higher odds of having high SB measured as non-upright time greater than 23 h/day (odds ratio (OR): 1.050, 95% confidence interval (CI): 1.000-1.102). Individuals having 1-year higher age deviation trended towards lower odds of having high levels of PA measured as stepping time greater than 7.4 min/day (OR: 0.916, CI: 0.836-1.005) and as greater than 19.5 sit-to-stand transitions/day (OR: 0.915, CI: 0.836-1.002). In conclusion, higher biological age was associated with higher levels of SB and trended towards lower PA. Incorporating blood biological age could facilitate resource allocation and the development of more tailored rehabilitation plans.

Keywords: Accelerometry; Ageing; Physical activity; Rehabilitation; Sedentary behaviour.

Abstract

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