A case of intracranial infection caused by Aspergillus flavus originating from chronic otitis media

Ling Yang; Jiacun Su; Chao Zhuo

doi:10.1016/j.mmcr.2024.100637

A case of intracranial infection caused by Aspergillus flavus originating from chronic otitis media

Med Mycol Case Rep. 2024 Feb 28:44:100637. doi: 10.1016/j.mmcr.2024.100637. eCollection 2024 Jun.

Authors

Ling Yang¹, Jiacun Su², Chao Zhuo¹

Affiliations

¹ Department of Infection, The First Hospital of Guangzhou Medical University, Guangzhou, 510000, China.
² Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, 200040, China.

Abstract

Central nervous system (CNS) aspergillosis is uncommon in immunocompetent patients. We present a 64-year-old man with chronic otitis media and uncontrolled diabetes. Aspergillus flavus was identified in cerebrospinal fluid via metagenomics next-generation sequencing technology. Initial voriconazole treatment offered limited relief, but personalized dosage adjustments, guided by drug concentration, led to remission. This case underscores the importance of diverse diagnostic approaches and tailored therapy for CNS Aspergillus infections.

Keywords: Central nervous system aspergillosis; Next-generation sequencing; Voriconazole concentration.

Publication types

Case Reports