No genetic causality between obesity and benign paroxysmal vertigo: A two-sample Mendelian randomization study

Zhiyan Guo; Bingyu Huang; Lingxiao Gan; Shanshan Liang; Ying Liu

doi:10.1515/med-2024-0940

No genetic causality between obesity and benign paroxysmal vertigo: A two-sample Mendelian randomization study

Open Med (Wars). 2024 Apr 5;19(1):20240940. doi: 10.1515/med-2024-0940. eCollection 2024.

Authors

Zhiyan Guo¹, Bingyu Huang¹, Lingxiao Gan¹, Shanshan Liang¹, Ying Liu²

Affiliations

¹ Department of Rehabilitation, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
² Department of Rehabilitation, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Qingxiu District, Nanning, Guangxi, China.

Abstract

Objective: We applied Mendelian randomization to explore the causal relationship between obesity and benign paroxysmal vertigo (BPV).

Methods: We chose two types of obesity diseases. Obesity due to excessive calories and other or unspecified obesity from the FinnGen database. We used genomic significance (p < 5 × 10^-8) to obtain independent single nucleotide polymorphisms (SNPs) as instrumental variables. Similarly, genome-wide association study data for the disease BPV were selected from the FinnGen database. R was then used to test the data for multiplicity and heterogeneity, as well as to detect the effect of individual SNPs on the results. Random effects inverse variance weighting was used as the main statistical analysis.

Results: First, by analyzing, we found an outlier in obesity due to excessive calories (rs12956821). Outliers were then removed, and the statistical results were analyzed without heterogeneity (p > 0.05) and horizontal pleiotropy (p > 0.05), as well as individual SNPs having no effect on the results. Meanwhile, random-effects IVW results showed obesity due to excessive calories (p = 0.481; OR = 0.941), and other or unspecified obesity (p = 0.640; OR = 0.964).

Conclusions: The present study did not find a causal relationship between the above two obesity types and BPV at the genetic level.

Keywords: Mendelian randomization; benign paroxysmal vertigo; genome-wide association study; obesity.