Synthesis and crystal structure of N-phenyl-2-(phenyl-sulfan-yl)acetamide

Reham A Mohamed-Ezzat; Benson M Kariuki; Galal H Elgemeie

doi:10.1107/S2056989024002573

Synthesis and crystal structure of N-phenyl-2-(phenyl-sulfan-yl)acetamide

Acta Crystallogr E Crystallogr Commun. 2024 Mar 26;80(Pt 4):392-395. doi: 10.1107/S2056989024002573. eCollection 2024 Mar 1.

Authors

Reham A Mohamed-Ezzat¹, Benson M Kariuki², Galal H Elgemeie³

Affiliations

¹ Chemistry of Natural & Microbial Products Department, Pharmaceutical and Drug Industries Research Institute, National Research Center, Cairo, Egypt.
² School of Chemistry, Cardiff University, Main Building, Park Place, Cardiff CF10, 3AT, United Kingdom.
³ Department of Chemistry, Faculty of Science, Helwan University, Helwan, Cairo, Egypt.

Abstract

N-Phenyl-2-(phenyl-sulfan-yl)acetamide, C₁₄H₁₃NOS, was synthesized and structurally characterized. In the crystal, N-H⋯O hydrogen bonding leads to the formation of chains of mol-ecules along the [100] direction. The chains are linked by C-H⋯π inter-actions, forming a three-dimensional network. The crystal studied was twinned by a twofold rotation around [100].

Keywords: acetamide; crystal structure; sulfide; synthesis.