All-Arthroscopic Matrix-Associated Autologous Chondrocyte Implantation for a Trochlear Defect

Ting Zhang; Fauzan Akhter; Mahmoud Almasri; Brian J Chilelli

doi:10.1016/j.eats.2023.102895

All-Arthroscopic Matrix-Associated Autologous Chondrocyte Implantation for a Trochlear Defect

Arthrosc Tech. 2024 Jan 11;13(3):102895. doi: 10.1016/j.eats.2023.102895. eCollection 2024 Mar.

Authors

Ting Zhang¹, Fauzan Akhter¹, Mahmoud Almasri¹, Brian J Chilelli¹

Affiliation

¹ Mercy Health-Cincinnati SportsMedicine and Orthopaedic Center, Cincinnati SportsMedicine Research and Education Foundation, Cincinnati, Ohio, U.S.A.

Abstract

Matrix-associated autologous chondrocyte implantation (MACI) is a 2-step technique designed to treat symptomatic full-thickness articular cartilage defects of the knee. In this technique article, MACI (autologous cultured chondrocytes on porcine collagen membrane) is used to treat a femoral trochlear defect of the knee. Treating a defect with this technique leads to improved clinical outcomes by restoring the native chondral surface architecture and biomechanics of the knee. In addition, it has the potential to prevent or delay further progressive degeneration of the joint. It is a 2-stage procedure consisting of an initial arthroscopic cartilage biopsy, followed by 4 to 6 weeks of in vitro chondrocyte expansion and, finally, re-implantation. We recommend performing the MACI procedure arthroscopically for the second stage to treat a femoral trochlear defect. During the second surgical procedure, we examine and prepare the recipient site, followed by graft introduction in an all-arthroscopic manner via dry scoping, secured by a thin layer of fibrin glue.