SALL4 in gastrointestinal tract cancers: upstream and downstream regulatory mechanisms

Mol Med. 2024 Apr 8;30(1):46. doi: 10.1186/s10020-024-00812-z.

Abstract

Effective therapeutic targets and early diagnosis are major challenges in the treatment of gastrointestinal tract (GIT) cancers. SALL4 is a well-known transcription factor that is involved in organogenesis during embryonic development. Previous studies have revealed that SALL4 regulates cell proliferation, survival, and migration and maintains stem cell function in mature cells. Additionally, SALL4 overexpression is associated with tumorigenesis. Despite its characterization as a biomarker in various cancers, the role of SALL4 in GIT cancers and the underlying mechanisms are unclear. We describe the functions of SALL4 in GIT cancers and discuss its upstream/downstream genes and pathways associated with each cancer. We also consider the possibility of targeting these genes or pathways as potential therapeutic options for GIT cancers.

Keywords: Downstream target; Gastrointestinal tract cancer; SALL4; Upstream regulation.

Publication types

  • Review

MeSH terms

  • Cell Line, Tumor
  • Embryonic Development
  • Gastrointestinal Neoplasms* / genetics
  • Humans
  • Stem Cells / metabolism
  • Transcription Factors* / genetics
  • Transcription Factors* / metabolism

Substances

  • Transcription Factors
  • SALL4 protein, human