O-linked β-N-acetylglucosaminylation may be a key regulatory factor in promoting osteogenic differentiation of bone marrow mesenchymal stromal cells

Xu-Chang Zhou; Guo-Xin Ni

doi:10.4252/wjsc.v16.i3.228

O-linked β-N-acetylglucosaminylation may be a key regulatory factor in promoting osteogenic differentiation of bone marrow mesenchymal stromal cells

World J Stem Cells. 2024 Mar 26;16(3):228-231. doi: 10.4252/wjsc.v16.i3.228.

Authors

Xu-Chang Zhou¹, Guo-Xin Ni²

Affiliations

¹ School of Sport Medicine and Rehabilitation, Beijing Sport University, Beijing 100084, China.
² Department of Rehabilitation Medicine, The First Affiliated Hospital of Xiamen University, Xiamen 361003, Fujian Province, China. nigx@xmu.edu.cn.

Abstract

Cumulative evidence suggests that O-linked β-N-acetylglucosaminylation (O-GlcNAcylation) plays an important regulatory role in pathophysiological processes. Although the regulatory mechanisms of O-GlcNAcylation in tumors have been gradually elucidated, the potential mechanisms of O-GlcNAcylation in bone metabolism, particularly, in the osteogenic differentiation of bone marrow mesenchymal stromal cells (BMSCs) remains unexplored. In this study, the literature related to O-GlcNAcylation and BMSC osteogenic differentiation was reviewed, assuming that it could trigger more scholars to focus on research related to O-GlcNAcylation and bone metabolism and provide insights into the development of novel therapeutic targets for bone metabolism disorders such as osteoporosis.

Keywords: Bone marrow mesenchymal stromal cells; O-GlcNAcylation; Osteogenic differentiation; Osteoporosis.

Publication types

Editorial