Wild-type Transthyretin Amyloid Deposition in an Ascending Aortic Aneurysm

Abbas Hoteit; Faye Victoria C Casimero; James R Stone; Duke Cameron; Eric M Isselbacher; Reza Seyedsadjadi; Hanna K Gaggin

doi:10.1016/j.jaccas.2024.102311

Wild-type Transthyretin Amyloid Deposition in an Ascending Aortic Aneurysm

JACC Case Rep. 2024 Mar 28;29(9):102311. doi: 10.1016/j.jaccas.2024.102311. eCollection 2024 May 1.

Authors

Abbas Hoteit¹, Faye Victoria C Casimero², James R Stone², Duke Cameron³, Eric M Isselbacher⁴, Reza Seyedsadjadi⁵, Hanna K Gaggin^{1

6}

Affiliations

¹ Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts, USA.
² Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
³ Department of Cardiac Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA.
⁴ Thoracic Aortic Center and Heart Center, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts, USA.
⁵ Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
⁶ Harvard Medical School, Boston, Massachusetts, USA.

Abstract

Amyloid deposition in aortic tissue is associated with increased stiffness. We report a patient with ascending aortic aneurysm and chronic abdominal aortic dissection who had significant wild-type transthyretin amyloid deposition on surgical pathology. The patient did not have cardiac involvement on further workup.

Keywords: ascending aortic aneurysm; transthyretin amyloidosis.