Osteosarcoma-targeted Cu and Ce based oxide nanoplatform for NIR II fluorescence/magnetic resonance dual-mode imaging and ros cascade amplification along with immunotherapy

Mo Cheng; Qingjie Kong; Qing Tian; Weiluo Cai; Chunmeng Wang; Minjia Yuan; Wenxing Wang; Peiyuan Wang; Wangjun Yan

doi:10.1186/s12951-024-02400-z

Osteosarcoma-targeted Cu and Ce based oxide nanoplatform for NIR II fluorescence/magnetic resonance dual-mode imaging and ros cascade amplification along with immunotherapy

J Nanobiotechnology. 2024 Apr 4;22(1):151. doi: 10.1186/s12951-024-02400-z.

Authors

Mo Cheng¹, Qingjie Kong², Qing Tian³, Weiluo Cai¹, Chunmeng Wang¹, Minjia Yuan^{4

5}, Wenxing Wang⁶, Peiyuan Wang⁷, Wangjun Yan⁸

Affiliations

¹ Department of Musculoskeletal Surgery of Shanghai Cancer Center, Fudan University, Shanghai, 200032, P. R. China.
² Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, P. R. China.
³ Department of Neurology, Qingpu Branch of Zhongshan Hospital, Fudan University, Shanghai, 201799, P. R. China.
⁴ Department of Chemistry, iChEM (Collaborative Innovation Center of Chemistry for Energy Materials), Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, State Key Laboratory of Molecular Engineering of Polymers, Laboratory of Advanced Materials, Fudan University, Shanghai, 200433, P. R. China.
⁵ Shanghai Qiran Biotechnology Co., Ltd, Shanghai, 201702, China.
⁶ Department of Chemistry, iChEM (Collaborative Innovation Center of Chemistry for Energy Materials), Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, State Key Laboratory of Molecular Engineering of Polymers, Laboratory of Advanced Materials, Fudan University, Shanghai, 200433, P. R. China. wangwenxing@fudan.edu.cn.
⁷ Key Laboratory of Design and Assembly of Functional Nanostructures, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, 350002, P. R. China. wangpeiyuan@fjirsm.ac.cn.
⁸ Department of Musculoskeletal Surgery of Shanghai Cancer Center, Fudan University, Shanghai, 200032, P. R. China. yanwj@fudan.edu.cn.

Abstract

Background: As the lethal bone tumor, osteosarcoma often frequently occurs in children and adolescents with locally destructive and high metastasis. Distinctive kinds of nanoplatform with high therapeutical effect and precise diagnosis for osteosarcoma are urgently required. Multimodal optical imaging and programmed treatment, including synergistic photothermal-chemodynamic therapy (PTT-CDT) elicits immunogenetic cell death (ICD) is a promising strategy that possesses high bio-imaging sensitivity for accurate osteosarcoma delineating as well as appreciable therapeutic efficacy with ignorable side-effects.

Methods and results: In this study, mesoporous Cu and Ce based oxide nanoplatform with Arg-Gly-Asp (RGD) anchoring is designed and successfully constructed. After loading with indocyanine green, this nanoplatform can be utilized for precisely targeting and efficaciously ablating against osteosarcoma via PTT boosted CDT and the closely following ICD stimulation both in vitro and in vivo. Besides, it provides off-peak fluorescence bio-imaging in the second window of near-infrared region (NIR II, 1000-1700 nm) and Magnetic resonance signal, serves as the dual-mode contrast agents for osteosarcoma tissue discrimination.

Conclusion: Tumor targeted Cu&Ce based mesoporous nanoplatform permits efficient osteosarcoma suppression and dual-mode bio-imaging that opens new possibility for effectively diagnosing and inhibiting the clinical malignant osteosarcoma.

MeSH terms

Adolescent
Bone Neoplasms* / diagnostic imaging
Bone Neoplasms* / drug therapy
Cell Line, Tumor
Child
Humans
Immunotherapy
Magnetic Resonance Imaging / methods
Magnetic Resonance Spectroscopy
Nanoparticles*
Neoplasms*
Osteosarcoma* / diagnostic imaging
Osteosarcoma* / therapy
Phototherapy

Grants and funding

82072972/National Natural Science Foundation