Advances in Systemic Therapy in Pancreatic Cancer

Hematol Oncol Clin North Am. 2024 Jun;38(3):617-627. doi: 10.1016/j.hoc.2024.03.002. Epub 2024 Apr 4.

Abstract

Substantial progress has been made toward understanding biology and developing new therapies for pancreatic ductal adenocarcinoma (PDAC). In this review, new insights from genomic profiling, as well as implications for treatment and prognosis, are discussed. New standards of care approaches with a focus on drug therapies are discussed for the treatment of resectable and advanced PDAC. The role of targeted and immune therapies remains limited; cohorts likely to benefit from these approaches are discussed. Promising, preliminary results regarding experimental therapies are reviewed.

Keywords: DNA damage repair; Immunotherapy; Kirsten rat sarcoma viral oncogene homolog (KRAS); Mismatch repair; Pancreatic adenocarcinoma; poly(adenosine diphosphate-ribose) polymerase (PARP).

Publication types

  • Review

MeSH terms

  • Carcinoma, Pancreatic Ductal* / drug therapy
  • Carcinoma, Pancreatic Ductal* / genetics
  • Carcinoma, Pancreatic Ductal* / pathology
  • Carcinoma, Pancreatic Ductal* / therapy
  • Humans
  • Immunotherapy / methods
  • Molecular Targeted Therapy / methods
  • Pancreatic Neoplasms* / drug therapy
  • Pancreatic Neoplasms* / genetics
  • Pancreatic Neoplasms* / therapy
  • Prognosis