Subcutaneous panniculitis-like T-cell lymphoma: fever and facial swelling with hemophagocytic syndrome

BMJ Case Rep. 2024 Apr 2;17(4):e256615. doi: 10.1136/bcr-2023-256615.

Abstract

We report a case of subcutaneous panniculitis-like T-cell lymphoma (SPTCL) in a young man presenting with fever and facial swelling. He had pancytopenia and hemophagocytic syndrome (HPS) on evaluation. The histopathological examination of skin punch biopsy from the face and chest wall showed SPTCL. Given the associated HPS, he was started on steroid and multidrug chemotherapy following which he had symptomatic improvement.

Keywords: Haematology (incl blood transfusion); Malignant and Benign haematology; Medical management; Skin cancer.

Publication types

  • Case Reports

MeSH terms

  • Angioedema* / pathology
  • Fever / etiology
  • Humans
  • Lymphohistiocytosis, Hemophagocytic* / diagnosis
  • Lymphohistiocytosis, Hemophagocytic* / drug therapy
  • Lymphohistiocytosis, Hemophagocytic* / etiology
  • Lymphoma, T-Cell* / complications
  • Lymphoma, T-Cell* / diagnosis
  • Lymphoma, T-Cell* / drug therapy
  • Male
  • Panniculitis* / diagnosis
  • Panniculitis* / drug therapy
  • Panniculitis* / etiology
  • Skin / pathology

Supplementary concepts

  • Subcutaneous panniculitis-like T-cell lymphoma