Chemical characterisation of essential oil from Sambucus williamsii Hance leaves and its hepatoprotective effects

Xianqun Meng; Dan Wang; Qiushi Hu; Shanshan Liang; Qing Wei; Tingguo Kang; Xiansheng Meng

doi:10.1080/14786419.2024.2327637

Chemical characterisation of essential oil from Sambucus williamsii Hance leaves and its hepatoprotective effects

Nat Prod Res. 2024 Apr 3:1-6. doi: 10.1080/14786419.2024.2327637. Online ahead of print.

Authors

Xianqun Meng¹, Dan Wang¹, Qiushi Hu¹, Shanshan Liang², Qing Wei², Tingguo Kang¹, Xiansheng Meng¹

Affiliations

¹ Department of Traditional Chinese Medicine Identification, Liaoning University of Traditional Chinese Medicine, Dalian, China.
² Plant Polysaccharide Research Center, Guizhou University of Traditional Chinese Medicine, Guiyang, China.

PMID: 38567651
DOI: 10.1080/14786419.2024.2327637

Abstract

This study is the first to examine the effect of leaves of Sambucus williamsii Hance essential oil on acute liver injury. According to gas chromatography-mass spectrometry analysis, the major constituents of S. williamsii essential oil (SEO)were (S)-falcarinol (62.66%), 17-pentatriacontene (7.78%) and tetrapentacontane (8.64%). Mice were pre-treated with SEO for 6 days followed by inducing liver injury with CCl₄. The results indicated that SEO protected the liver against CCl₄-induced injuries. Elevated levels of alanine-aminotransferase (ALT), aspartate amino-transferase (AST), alkaline phosphatase (ALP) in serum were significantly reduced on SEO pre-treatment. SEO pre-treatment significantly inhibited the oxidative stress and inflammation. Furthermore, toll-like receptor-4 (TLR4)/nuclear factor kappa-B (NF-κB) signalling pathways were significantly modulated by SEO in the liver tissue. The findings demonstrate that the essential oil of S. williamsii has enhancing the resistance to CCl₄-induced liver injury.

Keywords: Essential oil from sambucus williamsii hance leaves; TLR4/NF-κB signalling pathways; hepatoprotective effects.