Post-COVID syndrome: analysis of the prevalence of chemosensory dysfunction and predictive factors of recovery in COVID-19 long-haulers in Jordan

Eur Rev Med Pharmacol Sci. 2024 Mar;28(6):2593-2604. doi: 10.26355/eurrev_202403_35765.

Abstract

Objective: One of the major concerns of the post-COVID-19 era is elucidating and addressing the long-term complications of COVID-19.

Subjects and methods: A web-based questionnaire was distributed in Jordan to assess the prevalence and recovery from chemosensory dysfunction among COVID-19 long-haulers in Jordan.

Results: A total of 611 respondents complained of chemosensory dysfunction (age range = 18-68 years), and the majority of the respondents were female (88.4%). Parosmia was the most prevalent olfactory dysfunction reported (n = 337, 33.3%), and parageusia was the most frequently reported gustatory dysfunction (n = 239, 36.4%). Medications were not reported to be associated with a better perception of smell or taste by nearly half of those who had been treated (n = 146, 46.1%). Among participants who had received olfactory rehabilitation/training (n = 215, 35.2%), 43.7% (n = 94) reported modest improvement, with the most frequently helpful scents being coffee (n = 80, 24.8%), aromatic oils (n = 74, 23%), and perfumes/colognes (n = 73, 22.7%). Age was found to have a significant negative correlation with complete recovery. In addition, age (p < .05), anosmia (p < .001), hyperosmia (p < .001), ageusia (p < .05), and duration of olfactory dysfunction (p < .001) were all independent predictors of complete recovery.

Conclusions: Chemosensory dysfunctions are largely subjective; therefore, more objective examinations are required to draw more definite conclusions.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • COVID-19* / epidemiology
  • Female
  • Humans
  • Jordan / epidemiology
  • Male
  • Middle Aged
  • Olfaction Disorders* / epidemiology
  • Prevalence
  • Smell
  • Syndrome
  • Young Adult