A systematic review and meta-analysis of radiotherapy and particle beam therapy for skull base chondrosarcoma: TRP-chondrosarcoma 2024

Masatoshi Nakamura; Masashi Mizumoto; Takashi Saito; Shosei Shimizu; Yinuo Li; Yoshiko Oshiro; Masako Inaba; Sho Hosaka; Hiroko Fukushima; Ryoko Suzuki; Takashi Iizumi; Kei Nakai; Kazushi Maruo; Hideyuki Sakurai

doi:10.3389/fonc.2024.1380716

A systematic review and meta-analysis of radiotherapy and particle beam therapy for skull base chondrosarcoma: TRP-chondrosarcoma 2024

Front Oncol. 2024 Mar 19:14:1380716. doi: 10.3389/fonc.2024.1380716. eCollection 2024.

Authors

Affiliations

¹ Department of Radiation Oncology, University of Tsukuba, Tsukuba, Japan.
² Department of Pediatric Radiation Therapy Center/Pediatric Proton Beam Therapy Center, Hebei Yizhou Cancer Hospital, Zhuozhou, China.
³ Department of Radiation Oncology, Tsukuba Medical Center Hospital, Tsukuba, Japan.
⁴ Department of Pediatrics, University of Tsukuba Hospital, Tsukuba, Japan.
⁵ Department of Child Health, Institute of Medicine, University of Tsukuba, Tsukuba, Japan.
⁶ Department of Biostatistics, Institute of Medicine, University of Tsukuba, Tsukuba, Japan.

Abstract

Introduction: Chondrosarcoma is a rare malignant bone tumor. Particle beam therapy (PT) can concentrate doses to targets while reducing adverse events. A meta-analysis based on a literature review was performed to examine the efficacy of PT and photon radiotherapy for skull base chondrosarcoma.

Methods: The meta-analysis was conducted using 21 articles published from 1990 to 2022.

Results: After PT, the 3- and 5-year overall survival (OS) rates were 94.1% (95% confidence interval [CI]: 91.0-96.2%) and 93.9% (95% CI: 90.6-96.1%), respectively, and the 3- and 5-year local control rates were 95.4% (95% CI: 92.0-97.4%) and 90.1% (95% CI: 76.8-96.0%), respectively. Meta-regression analysis revealed a significant association of PT with a superior 5-year OS rate compared to three-dimensional conformal radiotherapy (p < 0.001). In the studies used in the meta-analysis, the major adverse event of grade 2 or higher was temporal lobe necrosis (incidence 1-18%, median 7%).

Conclusion: PT for skull base chondrosarcoma had a good outcome and may be a valuable option among radiotherapy modalities. However, high-dose postoperative irradiation of skull base chondrosarcoma can cause adverse events such as temporal lobe necrosis.

Keywords: TRP; chondrosarcoma; meta-analysis; proton; skull base; systematic review; temporal lobe necrosis.

Publication types

Systematic Review

Grants and funding

The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This work was supported by institutional funds only.