Antimicrobial-associated encephalopathy due to ampicillin

Naoya Mizutani; Tsuneaki Kenzaka

doi:10.1002/ccr3.8665

Antimicrobial-associated encephalopathy due to ampicillin

Clin Case Rep. 2024 Apr 2;12(4):e8665. doi: 10.1002/ccr3.8665. eCollection 2024 Apr.

Authors

Naoya Mizutani¹, Tsuneaki Kenzaka^{1

2}

Affiliations

¹ Department of Internal Medicine Hyogo Prefectural Tamba Medical Center Tamba Hyogo Japan.
² Division of Community Medicine and Career Development Kobe University Graduate School of Medicine Kobe Hyogo Japan.

Abstract

Because the β-lactam ring has a molecular structure similar to that of gamma-aminobutyric acid (GABA) neurotransmitters, it binds to GABA A receptors and inhibits GABAergic transmission, causing AAE. The possibility of antimicrobial-associated encephalopathy should be considered in cases of neurological or psychiatric symptoms after initiating an antimicrobial regimen.

Keywords: ampicillin; antimicrobial‐associated encephalopathy; beta‐lactams; penicillin; seizures.

Publication types

Case Reports