Toonanoronoids A-E, five new limonoids from Toona ciliata var. yunnanensis

Fitoterapia. 2024 Mar 31:175:105938. doi: 10.1016/j.fitote.2024.105938. Online ahead of print.

Abstract

Five new B-seco-limonoids, namely toonanoronoids A-E (1-5), in conjunction with three previously reported compounds, were isolated from the EtOAc extract of the twigs and leaves of Toona ciliata var. yunnanensis. Their structures were elucidated through comprehensive spectroscopic and X-ray crystallographic analysis. The cytotoxic activities of new compounds against five human tumor cell lines (HL-60, SMMC-7721, A549, MCF-7, and SW480) were screened, Compounds 4 and 5 exerted inhibition toward two tumor cell lines (HL-60, SW-480) with IC50 values between 1.7 and 5.9 μM.

Keywords: B-seco-limonoids; Cytotoxic activity; Meliaceae; Toona ciliata var. yunnanensis; X-ray crystallographic analysis.