Deep partially linear cox model for current status data

Biometrics. 2024 Mar 27;80(2):ujae024. doi: 10.1093/biomtc/ujae024.

Abstract

Deep learning has continuously attained huge success in diverse fields, while its application to survival data analysis remains limited and deserves further exploration. For the analysis of current status data, a deep partially linear Cox model is proposed to circumvent the curse of dimensionality. Modeling flexibility is attained by using deep neural networks (DNNs) to accommodate nonlinear covariate effects and monotone splines to approximate the baseline cumulative hazard function. We establish the convergence rate of the proposed maximum likelihood estimators. Moreover, we derive that the finite-dimensional estimator for treatment covariate effects is $\sqrt{n}$-consistent, asymptotically normal, and attains semiparametric efficiency. Finally, we demonstrate the performance of our procedures through extensive simulation studies and application to real-world data on news popularity.

Keywords: current status data; deep learning; modeling flexibility; monotone splines; semiparametric efficiency.

MeSH terms

  • Computer Simulation
  • Likelihood Functions
  • Linear Models
  • Proportional Hazards Models*
  • Survival Analysis