Chronological pattern of venous thromboembolism (VTE) occurrence impacts in survival of pancreatic ductal adenocarcinoma (PDAC)

Irene González Caraballo; Rocío Martín Lozano; Roberto Jiménez Rodríguez; Javier Soto Alsar; Laura Ortega Morán; Miguel Martín Jiménez; Andrés J Muñoz Martín

doi:10.1007/s12094-024-03467-8

Chronological pattern of venous thromboembolism (VTE) occurrence impacts in survival of pancreatic ductal adenocarcinoma (PDAC)

Clin Transl Oncol. 2024 Apr 1. doi: 10.1007/s12094-024-03467-8. Online ahead of print.

Authors

Irene González Caraballo¹, Rocío Martín Lozano², Roberto Jiménez Rodríguez², Javier Soto Alsar², Laura Ortega Morán², Miguel Martín Jiménez², Andrés J Muñoz Martín²

Affiliations

¹ Medical Oncology Service, Hospital General Universitario Gregorio Marañón, Madrid, Spain. irene.gctm@gmail.com.
² Medical Oncology Service, Hospital General Universitario Gregorio Marañón, Madrid, Spain.

PMID: 38558283
DOI: 10.1007/s12094-024-03467-8

Abstract

Background: Limited data exist on the prognostic significance of the chronology of VTE in patients with PDAC.

Methods: Medical data and survival characteristics of patients treated for PDAC from 2019 to 2021 were retrospectively reviewed. Early VTE was defined as occurring within the three months of PDAC diagnosis.

Results: 197 patients were included, 54 (27.4%) developed a VTE. Early appearance of VTE was associated with worse prognosis: median overall survival (mOS) VTE < 3 months 8.5 months (HR 1.65, 95% CI 1.11-2.46; p = 0.014), mOS VTE > 3 months 12.8 months (HR 0.78, 95% CI 0.39-1.54; p = 0.5) and mOS patients without VTE 11.4 months (95% CI 10.1-15.4). There was no significant association between the patient's VTE risk according to the Khorana risk score (KRS) (chi2 test p-value = 0.9).

Conclusion: Early VTE is a prognostic factor in PDAC, which may identify a more aggressive subtype.

Keywords: Early thrombosis; Pancreatic cancer; Prognosis; VTE.