Insights on E1-like enzyme ATG7: functional regulation and relationships with aging-related diseases

Jingwei Liu; Yutong Xiao; Liangzi Cao; Songming Lu; Siyi Zhang; Ruohan Yang; Yubang Wang; Naijin Zhang; Yang Yu; Xiwen Wang; Wendong Guo; Zhuo Wang; Hongde Xu; Chengzhong Xing; Xiaoyu Song; Liu Cao

doi:10.1038/s42003-024-06080-1

Insights on E1-like enzyme ATG7: functional regulation and relationships with aging-related diseases

Commun Biol. 2024 Mar 29;7(1):382. doi: 10.1038/s42003-024-06080-1.

Authors

Jingwei Liu^#^{1

2

3}, Yutong Xiao^#^{1

2}, Liangzi Cao^{1

2}, Songming Lu^{1

2}, Siyi Zhang^{1

2}, Ruohan Yang^{1

2}, Yubang Wang^{1

2}, Naijin Zhang^{1

4}, Yang Yu^{1

2}, Xiwen Wang⁵, Wendong Guo^{1

2}, Zhuo Wang^{1

2}, Hongde Xu^{6

7}, Chengzhong Xing⁸, Xiaoyu Song^{9

10}, Liu Cao^{11

12}

Affiliations

¹ The College of Basic Medical Science, Health Sciences Institute, China Medical University, Shenyang, Liaoning, China.
² Key Laboratory of Cell Biology of Ministry of Public Health, Key Laboratory of Medical Cell Biology of Ministry of Education, Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors (China Medical University), Ministry of Education, Liaoning Province Collaborative Innovation Center of Aging Related Disease Diagnosis and Treatment and Prevention, China Medical University, Shenyang, Liaoning, China.
³ Department of Anus and Intestine Surgery, First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.
⁴ Department of Cardiology, First Hospital of China Medical University, Key Laboratory of Environmental Stress and Chronic Disease Control and Prevention, Ministry of Education, China Medical University, Shenyang, Liaoning, China.
⁵ Department of Thoracic Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.
⁶ The College of Basic Medical Science, Health Sciences Institute, China Medical University, Shenyang, Liaoning, China. hdxu@cmu.edu.cn.
⁷ Key Laboratory of Cell Biology of Ministry of Public Health, Key Laboratory of Medical Cell Biology of Ministry of Education, Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors (China Medical University), Ministry of Education, Liaoning Province Collaborative Innovation Center of Aging Related Disease Diagnosis and Treatment and Prevention, China Medical University, Shenyang, Liaoning, China. hdxu@cmu.edu.cn.
⁸ Department of Anus and Intestine Surgery, First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China. xcz1966@126.com.
⁹ The College of Basic Medical Science, Health Sciences Institute, China Medical University, Shenyang, Liaoning, China. xysong@cmu.edu.cn.
¹⁰ Key Laboratory of Cell Biology of Ministry of Public Health, Key Laboratory of Medical Cell Biology of Ministry of Education, Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors (China Medical University), Ministry of Education, Liaoning Province Collaborative Innovation Center of Aging Related Disease Diagnosis and Treatment and Prevention, China Medical University, Shenyang, Liaoning, China. xysong@cmu.edu.cn.
¹¹ The College of Basic Medical Science, Health Sciences Institute, China Medical University, Shenyang, Liaoning, China. lcao@cmu.edu.cn.
¹² Key Laboratory of Cell Biology of Ministry of Public Health, Key Laboratory of Medical Cell Biology of Ministry of Education, Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors (China Medical University), Ministry of Education, Liaoning Province Collaborative Innovation Center of Aging Related Disease Diagnosis and Treatment and Prevention, China Medical University, Shenyang, Liaoning, China. lcao@cmu.edu.cn.

^# Contributed equally.

Abstract

Autophagy is a dynamic self-renovation biological process that maintains cell homeostasis and is responsible for the quality control of proteins, organelles, and energy metabolism. The E1-like ubiquitin-activating enzyme autophagy-related gene 7 (ATG7) is a critical factor that initiates classic autophagy reactions by promoting the formation and extension of autophagosome membranes. Recent studies have identified the key functions of ATG7 in regulating the cell cycle, apoptosis, and metabolism associated with the occurrence and development of multiple diseases. This review summarizes how ATG7 is precisely programmed by genetic, transcriptional, and epigenetic modifications in cells and the relationship between ATG7 and aging-related diseases.

Publication types

Review

MeSH terms

Autophagosomes* / metabolism
Autophagy* / genetics
Autophagy-Related Protein 7 / genetics
Ubiquitin-Activating Enzymes / metabolism
Ubiquitin-Conjugating Enzymes / metabolism

Substances

Autophagy-Related Protein 7
Ubiquitin-Activating Enzymes
Ubiquitin-Conjugating Enzymes