Retinal Ischemic Perivascular Lesions Are Associated With Myocardial Infarction in Patients With Coronary Artery Disease

Elodie Bousquet; Ahmad Santina; Adrian Au; Swathi Somisetty; Neda Abraham; Shilo Voichanski; Rania Estawro; Yousef A Fouad; Veronica Romero-Morales; Mathieu F Bakhoum; David Sarraf

doi:10.1016/j.ajo.2024.03.017

Retinal Ischemic Perivascular Lesions Are Associated With Myocardial Infarction in Patients With Coronary Artery Disease

Am J Ophthalmol. 2024 Mar 27:264:224-228. doi: 10.1016/j.ajo.2024.03.017. Online ahead of print.

Authors

Affiliations

¹ Form the Retinal Disorders and Ophthalmic Genetics Division (E.B., A.S., A.A., S.S., N.A., S.V., R.E., Y.A.F., V.R., D.S.), Stein Eye Institute, University of California Los Angeles, David Geffen School of Medicine at UCLA, Los Angeles, California, USA; Department of Ophthalmology (E.B.), University of Paris Cité, Lariboisière Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.
² Form the Retinal Disorders and Ophthalmic Genetics Division (E.B., A.S., A.A., S.S., N.A., S.V., R.E., Y.A.F., V.R., D.S.), Stein Eye Institute, University of California Los Angeles, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
³ Form the Retinal Disorders and Ophthalmic Genetics Division (E.B., A.S., A.A., S.S., N.A., S.V., R.E., Y.A.F., V.R., D.S.), Stein Eye Institute, University of California Los Angeles, David Geffen School of Medicine at UCLA, Los Angeles, California, USA; Retina unit, Ophthalmology Department (S.V.), Hadassah Medical Center and The Hebrew University of Jerusalem, Jerusalem, Israël.
⁴ Form the Retinal Disorders and Ophthalmic Genetics Division (E.B., A.S., A.A., S.S., N.A., S.V., R.E., Y.A.F., V.R., D.S.), Stein Eye Institute, University of California Los Angeles, David Geffen School of Medicine at UCLA, Los Angeles, California, USA; Retina Department (R.E.), Al-Watany Eye Hospital, Cairo, Egypt.
⁵ Form the Retinal Disorders and Ophthalmic Genetics Division (E.B., A.S., A.A., S.S., N.A., S.V., R.E., Y.A.F., V.R., D.S.), Stein Eye Institute, University of California Los Angeles, David Geffen School of Medicine at UCLA, Los Angeles, California, USA; Department of Ophthalmology (Y.A.F.), Ain Shams University Hospitals, Cairo, Egypt.
⁶ Form the Retinal Disorders and Ophthalmic Genetics Division (E.B., A.S., A.A., S.S., N.A., S.V., R.E., Y.A.F., V.R., D.S.), Stein Eye Institute, University of California Los Angeles, David Geffen School of Medicine at UCLA, Los Angeles, California, USA; Department of Retina (V.R.), Instituto Mexicano de Oftalmología, Querétaro, México.
⁷ Department of Ophthalmology and Visual Science (M.F.B.), Yale University School of Medicine, New Haven, USA; Department of Pathology (M.F.B.), Yale University School of Medicine, New Haven, USA; Yale Cancer Center (M.F.B.), Yale University, New Haven, USA.
⁸ Form the Retinal Disorders and Ophthalmic Genetics Division (E.B., A.S., A.A., S.S., N.A., S.V., R.E., Y.A.F., V.R., D.S.), Stein Eye Institute, University of California Los Angeles, David Geffen School of Medicine at UCLA, Los Angeles, California, USA; Greater Los Angeles VA Healthcare Center (D.S.), Los Angeles, California, USA. Electronic address: dsarraf@ucla.edu.

PMID: 38552932
DOI: 10.1016/j.ajo.2024.03.017

Abstract

Purpose: To evaluate the association of retinal ischemic perivascular lesions (RIPLs) with myocardial infarction (MI) among patients diagnosed with coronary artery diseases (CAD).

Design: Retrospective cross-sectional study.

Methods: Consecutive patients (317 patients) with CAD who underwent macular spectral domain optical coherence tomography (SD-OCT) were captured. Patients with CAD who developed MI were compared to those without MI. SD-OCT were reviewed by 2 independent and masked graders for the presence of RIPLs. Medical records were reviewed. Multivariate logistic regression analysis was used to evaluate the relationship between RIPLs and MI including the following covariates age, gender, smoking status, hypertension, diabetes, dyslipidemia and body mass index.

Results: Of 317 patients with CAD for whom OCT scans were available to study, there were 54 (17%) with a history of MI. A higher prevalence of RIPLs was observed in the MI group compared to the non-MI group (59.3% vs 35.7%; P < .001). The presence of RIPLs was significantly associated with MI with an odds ratio of 3 (1.91-4.74; P < .001), after adjusting for age, gender, smoking status, hypertension, diabetes, dyslipidemia, and body mass index.

Conclusions: The presence of RIPLs, detected with SD-OCT, is significantly associated with MI in patients with CAD. These findings underscore the potential clinical utility of incorporating RIPL evaluation in the medical management of CAD.

Published by Elsevier Inc.