Syk inhibition suppresses NLRP3 inflammasome activation in platelets from sickle cell mice leading to decreased platelet secretion, aggregation, spreading, and in vitro thrombus formation

Thromb Res. 2024 May:237:18-22. doi: 10.1016/j.thromres.2024.03.020. Epub 2024 Mar 22.

Authors

Sebastian Vogel¹, Sayuri Kamimura¹, Meghann L Smith¹, Luis E F Almeida¹, Xizhong Cui², Christian A Combs³, Zenaide M N Quezado⁴

Affiliations

¹ Department of Perioperative Medicine, National Institutes of Health Clinical Center, USA.
² Critical Care Medicine Department, National Institutes of Health Clinical Center, USA.
³ Light Microscopy Core, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
⁴ Department of Perioperative Medicine, National Institutes of Health Clinical Center, USA. Electronic address: zquezado@cc.nih.gov.

PMID: 38547689
DOI: 10.1016/j.thromres.2024.03.020

No abstract available

Keywords: Fostamatinib; NLRP3 inflammasome; Platelets; Sickle cell disease.

Publication types

Letter

MeSH terms

Anemia, Sickle Cell* / blood
Animals
Blood Platelets* / metabolism
Inflammasomes* / metabolism
Mice
NLR Family, Pyrin Domain-Containing 3 Protein* / metabolism
Platelet Aggregation* / drug effects
Syk Kinase* / antagonists & inhibitors
Syk Kinase* / metabolism
Thrombosis*

Substances

NLR Family, Pyrin Domain-Containing 3 Protein
Inflammasomes
Syk Kinase
Nlrp3 protein, mouse