Taxodin A, a Cytotoxic C30 Terpenoid from Taxodium mucronatum with a Unique Skeleton

Chem Biodivers. 2024 May;21(5):e202400648. doi: 10.1002/cbdv.202400648. Epub 2024 Apr 22.

Abstract

Taxodin A (1), a unique C30 terpenoid featuring an unprecedented skeleton composed of an abietane-type diterpene and a menthane-type monoterpene, was obtained from the leaves and branches of Taxodium mucronatum. The structure and absolute configuration of compound 1 was unequivocally established by the combination of extensive spectroscopic analyses and X-ray single-crystal diffraction analysis. Compound 1 exhibited potent cytotoxic activities against A549, SMMC-7721, MDA-MB-231, and SW480 cell lines with IC50 values of 15.35±0.73, 8.49±0.35, 17.53±0.79, 18.93±0.60 μM, respectively.

Keywords: Taxodin A; Taxodium mucronatum; cytotoxicity.

MeSH terms

  • Antineoplastic Agents, Phytogenic* / chemistry
  • Antineoplastic Agents, Phytogenic* / isolation & purification
  • Antineoplastic Agents, Phytogenic* / pharmacology
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Cell Survival / drug effects
  • Crystallography, X-Ray
  • Dose-Response Relationship, Drug
  • Drug Screening Assays, Antitumor*
  • Humans
  • Models, Molecular
  • Molecular Conformation
  • Molecular Structure
  • Plant Leaves / chemistry
  • Structure-Activity Relationship
  • Taxodium* / chemistry
  • Terpenes / chemistry
  • Terpenes / isolation & purification
  • Terpenes / pharmacology